Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Obes Surg. 2010 Feb;20(2):198-203. doi: 10.1007/s11695-009-9882-y. Epub 2009 Jun 9.
Recently, vaspin was identified as a novel adipokine with insulin-sensitizing effects that might be implicated in endogenous glucose regulation. Our objective was to evaluate the impact of acute weight loss and metabolic changes on serum vaspin concentrations in morbidly obese subjects following laparoscopic Roux-en-Y gastric bypass (RYGB) surgery.
Longitudinal, clinical intervention study in 33 morbidly obese subjects before and 12 months after RYGB was conducted. Fasting serum concentrations of vaspin were measured by a commercially available ELISA and correlated with BMI, parameters of insulin sensitivity, and other biochemical measurements. Fasting insulin sensitivity was estimated using the homeostasis model assessment (HOMA) of insulin resistance.
RYGB-induced weight loss resulted in a reduction of circulating vaspin, leptin, insulin, and C-peptide levels as well as of BMI, HbA1c, and HOMA (p < 0.0001, respectively). Changes in serum vaspin concentrations correlated positively with those in HOMA, insulin, C-peptide, HbA1c, and leptin (p < 0.05, respectively) levels. The association between percent change of vaspin and HOMA remained significant even after the adjustment for RYGB-induced changes in BMI.
Following RYGB surgery, changes in serum vaspin concentrations correlate significantly with the reduction of circulating leptin, insulin, and C-peptide levels and with the amelioration of insulin sensitivity. However, further studies have to elucidate whether vaspin is only a biomarker for body-weight-related changes of insulin sensitivity or whether it is implicated in the regulation of human glucose homeostasis.
最近，vaspin 被鉴定为一种具有胰岛素增敏作用的新型脂肪因子，可能与内源性葡萄糖调节有关。我们的目的是评估腹腔镜 Roux-en-Y 胃旁路 (RYGB) 手术后病态肥胖患者急性体重减轻和代谢变化对血清 vaspin 浓度的影响。
对 33 例病态肥胖患者进行前瞻性、临床干预研究，在 RYGB 术前和术后 12 个月进行。使用商业上可获得的 ELISA 测量空腹血清 vaspin 浓度，并将其与 BMI、胰岛素敏感性参数和其他生化测量值相关联。使用稳态模型评估（HOMA）胰岛素抵抗估计空腹胰岛素敏感性。
RYGB 诱导的体重减轻导致循环 vaspin、瘦素、胰岛素和 C 肽水平以及 BMI、HbA1c 和 HOMA 降低（分别为 p < 0.0001）。血清 vaspin 浓度的变化与 HOMA、胰岛素、C 肽、HbA1c 和瘦素（分别为 p < 0.05）水平呈正相关。即使在调整了 RYGB 诱导的 BMI 变化后，vaspin 百分比变化与 HOMA 之间的相关性仍然显著。
RYGB 手术后，血清 vaspin 浓度的变化与循环瘦素、胰岛素和 C 肽水平的降低以及胰岛素敏感性的改善显著相关。然而，还需要进一步的研究来阐明 vaspin 是否仅是与体重相关的胰岛素敏感性变化的生物标志物，还是参与了人类葡萄糖稳态的调节。
