Kosek Margaret, Lanata Claudio F, Black Robert E, Walker Damian G, Snyder John D, Salam Mohammed Abdus, Mahalanabis Dilip, Fontaine Olivier, Bhutta Zulfiqar A, Bhatnagar Shinjini, Rudan Igor
Department of International Health, Joins Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
J Health Popul Nutr. 2009 Jun;27(3):319-31. doi: 10.3329/jhpn.v27i3.3374.
Despite gains in controlling mortality relating to diarrhoeal disease, the burden of disease remains unacceptably high. To refocus health research to target disease-burden reduction as the goal of research in child health, the Child Health and Nutrition Research Initiative developed a systematic strategy to rank health research options. This priority-setting exercise included listing of 46 competitive research options in diarrhoeal disease and their critical and quantitative appraisal by 10 experts based on five criteria for research that reflect the ability of the research to be translated into interventions and achieved disease-burden reduction. These criteria included the answerability of the research questions; the efficacy and effectiveness of the intervention resulting from the research; the maximal potential for disease-burden reduction of the interventions derived from the research; the affordability, deliverability, and sustainability of the intervention supported by the research; and the overall effect of the research-derived intervention on equity. Experts scored each research option independently to delineate the best investments for diarrhoeal disease control in the developing world to reduce the burden of disease by 2015. Priority scores obtained for health policy and systems research obtained eight of the top 10 rankings in overall scores, indicating that current investments in health research are significantly different from those estimated to be the most effective in reducing the global burden of diarrhoeal disease by 2015.
尽管在控制腹泻病死亡率方面取得了进展，但疾病负担仍然高得令人无法接受。为了将卫生研究重新聚焦于以降低疾病负担为儿童健康研究的目标，儿童健康与营养研究倡议制定了一项系统战略，对卫生研究选项进行排名。这项确定优先事项的工作包括列出46项腹泻病竞争性研究选项，并由10位专家根据反映研究转化为干预措施并实现疾病负担降低能力的五项研究标准对其进行关键和定量评估。这些标准包括研究问题的可回答性；研究产生的干预措施的疗效和效果；研究得出的干预措施在降低疾病负担方面的最大潜力；研究支持的干预措施的可负担性、可提供性和可持续性；以及研究得出的干预措施对公平性的总体影响。专家们对每个研究选项进行独立评分，以确定在发展中国家控制腹泻病的最佳投资，到2015年减轻疾病负担。在总体得分中，卫生政策和系统研究获得的优先分数在前10名中占了8个，这表明目前对卫生研究的投资与预计到2015年在减轻全球腹泻病负担方面最有效的投资有很大不同。
