在混合感染期间向嗜NB性鼠白血病病毒捐赠N型或B型嗜性表型。
Donation of N- or B-tropic phenotype to NB-tropic murine leukemia virus during mixed infections.
作者信息
Kashmiri S V, Rein A, Bassin R H, Gerwin B I, Gisselbrecht S
出版信息
J Virol. 1977 Jun;22(3):626-33. doi: 10.1128/JVI.22.3.626-633.1977.
Abstract
The IC isolate of Moloney murine leukemia virus (MuLV), which is NB-tropic, was grown in cells producing conditionally defective or defective virus particles derived from N- or B-tropic MuLV. The infectious MuLV that was then released was found to be sensitive to Fv-1 restriction but produced NB-tropic progeny upon passage. These results indicate that this NB-tropic MuLV can acquire sensitivity to Fv-1 restriction by phenotypic mixing with N- or B-tropic MuLV. It is thus suggested that NB-tropic MuLV is insensitive to Fv-1 restriction simply because it lacks the determinants of tropism.
摘要
莫洛尼鼠白血病病毒（MuLV）的IC分离株具有嗜NB特性，它在产生源自嗜N或嗜B型MuLV的条件性缺陷或缺陷病毒颗粒的细胞中生长。随后释放的感染性MuLV被发现对Fv-1限制敏感，但传代后产生嗜NB特性的子代。这些结果表明，这种嗜NB特性的MuLV可通过与嗜N或嗜B型MuLV进行表型混合而获得对Fv-1限制的敏感性。因此提示，嗜NB特性的MuLV对Fv-1限制不敏感仅仅是因为它缺乏嗜性决定簇。
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