Gulhan Ibrahim, Eser Sultan, Yakut Cankut, Bige Ozgur, Ilhan Enver, Yildirim Yusuf, Saygili Ugur
Department of Obstetrics and Gynecology, Izmir Training and Research Hospital, Izmir, Turkey.
Int J Gynecol Cancer. 2009 May;19(4):648-50. doi: 10.1111/IGC.0b013e3181a12e8b.
To determine the risk of gynecologic cancers among women with previous breast cancer.
A population-based longitudinal study was conducted using the Izmir cancer registry center's data on 6356 breast cancer patients diagnosed in the period 1992 to 2006. Standardized incidence ratios (SIR) and absolute excess risks (AER) were calculated.
In total, 88 (1.3%) women developed a second primary cancer (other than second primary breast cancers) versus 49.8 expected (SIR, 1.76; 95% confidence interval [CI], 1.43-2.2; AER, 86.9/100.000 patients/y) and 33 of 88 (37.5%) women developed gynecologic cancer (21 endometrial, 8 ovarian, and 4 cervical) versus 8.8 expected (SIR, 4.03; 95% CI, 2.8-5.7; AER, 48.2/100.000 patients/y). High SIR and AER were observed for uterine (SIR,2.2; 95% CI, 1.5-2.7; AER, 35/100.000 patients/y), ovarian (SIR, 3.63; 95% CI, 1.6-7.2; AER, 12.2/100.000 patients/y), and cervical cancer (SIR, 1.68 95% CI: 0.46-4.3; AER, 2.2/100,000 patients/y).
Our data show that women with previous breast cancer have an elevated risk of developing a second primary gynecologic cancer compared with the general population. These patients should be followed up frequently.
确定既往患乳腺癌女性患妇科癌症的风险。
利用伊兹密尔癌症登记中心1992年至2006年期间诊断的6356例乳腺癌患者的数据进行基于人群的纵向研究。计算标准化发病比（SIR）和绝对超额风险（AER）。
共有88例（1.3%）女性发生了第二种原发性癌症（不包括第二种原发性乳腺癌），而预期为49.8例（SIR为1.76；95%置信区间[CI]为1.43 - 2.2；AER为86.9/100000患者/年），88例中有33例（37.5%）女性发生了妇科癌症（21例子宫内膜癌、8例卵巢癌和4例宫颈癌），而预期为8.8例（SIR为4.03；95% CI为2.8 - 5.7；AER为48.2/100000患者/年）。子宫癌（SIR为2.2；95% CI为1.5 - 2.7；AER为35/100000患者/年）、卵巢癌（SIR为3.63；95% CI为1.6 - 7.2；AER为12.2/100000患者/年）和宫颈癌（SIR为1.68，95% CI为0.46 - 4.3；AER为2.2/100000患者/年）的SIR和AER较高。
我们的数据表明，与普通人群相比，既往患乳腺癌的女性发生第二种原发性妇科癌症的风险升高。应对这些患者进行频繁随访。
