Volk N, Pompe-Kirn V
Cancer Registry of Slovenia, Institute of Oncology, Ljubljana.
Cancer Causes Control. 1997 Sep;8(5):764-70. doi: 10.1023/a:1018487506546.
Data from the Cancer Registry of Slovenia were used in a cohort study to determine whether the incidence of second primary cancers in patients with first primary breast cancer differs from the incidence expected in the general population. Special interest was given to long-term survivors. The expected numbers of second primary cancers were calculated by multiplying the number of appropriate person-years at risk by the corresponding age- and calendar-period-specific cancer incidence rates for women in Slovenia. The risk of a second primary cancer was expressed as the standardized incidence ratio (SIR). Of the 8,917 patients newly diagnosed in the period 1961-85 and followed-up to the end of 1994, 547 (6.2 percent) developed second primary cancers, whereas 410 (4.7 percent) were expected (SIR = 1.3, 95 percent confidence interval [CI] = 1.2-1.4). The risk was higher among younger patients. In long-term survivors, the risk was increased significantly for second primary cancer of the breast (SIR = 1.4, CI = 1.1-1.7), lung cancer (SIR = 1.6, CI = 1.1-2.3), melanoma (SIR = 2.7, CI = 1.5-4.4) and non-melanoma skin cancers(SIR = 2.0, CI = 1.6-2.4), corpus uteri cancer(SIR = 1.6, CI = 1.2-2.1), ovarian cancer(SIR = 2.3, CI = 1.7-3.0), and thyroid cancer (SIR = 2.5, CI = 1.2-4.6). Our results confirm the findings of several cohort studies carried out in Europe, the United States, and Japan, indicating that breast cancer patients should be monitored carefully for the occurrence of second primary cancers.
斯洛文尼亚癌症登记处的数据被用于一项队列研究，以确定首次患原发性乳腺癌患者的第二原发性癌症发病率是否与普通人群的预期发病率不同。研究特别关注长期存活者。第二原发性癌症的预期数量通过将适当的风险人年数乘以斯洛文尼亚女性相应年龄和日历期特定的癌症发病率来计算。第二原发性癌症的风险用标准化发病比（SIR）表示。在1961年至1985年期间新诊断并随访至1994年底的8917例患者中，547例（6.2%）发生了第二原发性癌症，而预期为410例（4.7%）（SIR = 1.3，95%置信区间[CI] = 1.2 - 1.4）。年轻患者的风险更高。在长期存活者中，乳腺癌（SIR = 1.4，CI = 1.1 - 1.7）、肺癌（SIR = 1.6，CI = 1.1 - 2.3）、黑色素瘤（SIR = 2.7，CI = 1.5 - 4.4）和非黑色素瘤皮肤癌（SIR = 2.0，CI = 1.6 - 2.4）、子宫体癌（SIR = 1.6，CI = 1.2 - 2.1）、卵巢癌（SIR = 2.3，CI = 1.7 - 3.0）和甲状腺癌（SIR = 2.5，CI = 1.2 - 4.6）的第二原发性癌症风险显著增加。我们的结果证实了在欧洲、美国和日本进行的几项队列研究的结果，表明乳腺癌患者应密切监测第二原发性癌症的发生。
