Teillol-Foo W L, Kassab J Y
Centre for Applied Statistics, University College of North Wales, Bangor.
Anaesthesia. 1991 Oct;46(10):881-4. doi: 10.1111/j.1365-2044.1991.tb09610.x.
One hundred and four children aged between 1 and 11 years were studied in a double-blind randomised controlled trial of glyceryl trinitrate ointment versus placebo, when used in addition to standard eutectic mixture of local anaesthetics cream. Each child received glyceryl trinitrate ointment on one hand and placebo on the other, and thus acted as his/her own control. A group of 30 children who received only the eutectic mixture on both hands (60 measurements) was also studied. The choice of site and ease of cannulation was scored. Skin colour and venous dilatation under the eutectic mixture were scored on a visual analogue scale. The addition of topical glyceryl trinitrate ointment to the standard eutectic mixture positively affected venous dilatation (p less than 0.01), choice of cannulation site (p less than 0.001), and ease of cannulation (p less than 0.001) of topical anaesthetic-treated skin.
在一项双盲随机对照试验中，对104名年龄在1至11岁之间的儿童进行了研究，比较硝酸甘油软膏与安慰剂在局部麻醉剂标准共熔混合物基础上使用时的效果。每个孩子一只手涂抹硝酸甘油软膏，另一只手涂抹安慰剂，因此每个孩子自身作为对照。还对一组30名双手仅涂抹共熔混合物的儿童（60次测量）进行了研究。对穿刺部位的选择和穿刺的难易程度进行评分。使用视觉模拟量表对共熔混合物下的皮肤颜色和静脉扩张情况进行评分。在局部麻醉处理的皮肤上，添加局部用硝酸甘油软膏对静脉扩张（p<0.01）、穿刺部位的选择（p<0.001）和穿刺的难易程度（p<0.001）有积极影响。
