Dogan Alev Aksoy, Cetin Emel Sesli, Hüssein Emad, Adiloglu Ali Kudret
Department of Orthodontics, Faculty of Dentistry, Süleyman Demirel University, Isparte, Turkey.
Angle Orthod. 2009 Jul;79(4):766-72. doi: 10.2319/062008-322.1.
To determine the absolute and relative antibacterial activity of octenidine dihydrochloride (OCT) against total and cariogenic bacteria in saliva samples of patients with fixed orthodontic appliances during 5 days of usage.
The study group consisted of 5 male and 13 female subjects who were selected from patients in the Clinic of Orthodontics. Each patient was given physiologic saline (PS), chlorhexidine gluconate (CHX), polyvinylpyrrolidone-iodine complex (PVP-I), and OCT every morning for 5 days, each separated by a 2-week interval. Total and cariogenic bacteria in saliva samples of orthodontically treated patients with fixed appliances were collected during 5 days of usage. Unstimulated saliva was collected as a baseline sample. Saliva samples were collected at 15 minutes, and on the second, third, and fifth day after rinsing the mouth with any of the solutions for 30 seconds, and bacterial counts were detected.
OCT showed an ultimate reduction of total viable oral bacteria, Lactobacillus species, and Streptococcus mutans in vivo. OCT also had a significantly greater inhibitory effect than 0.2% CHX and 7.5% PVP-I, from the beginning of the study until the fifth day after the orthodontic appliances were bonded (P < .1).
OCT compared favorably with respect to CHX and PVP-I complex in orthodontically treated patients with fixed appliances (P </= .1).
确定在使用5天期间，盐酸奥替尼啶（OCT）对佩戴固定正畸矫治器患者唾液样本中全部细菌和致龋菌的绝对及相对抗菌活性。
研究组由从正畸科诊所患者中选取的5名男性和13名女性受试者组成。每位患者每天早晨给予生理盐水（PS）、葡萄糖酸氯己定（CHX）、聚维酮碘复合物（PVP-I）和OCT，持续5天，每次给药间隔2周。在使用的5天内收集佩戴固定矫治器的正畸治疗患者唾液样本中的全部细菌和致龋菌。收集未刺激唾液作为基线样本。在用任何一种溶液漱口30秒后的15分钟以及第二天、第三天和第五天收集唾液样本，并检测细菌计数。
OCT在体内显示出对口腔总活菌、乳酸杆菌属和变形链球菌的最终减少作用。从研究开始到正畸矫治器粘结后的第五天，OCT的抑制作用也明显大于0.2% CHX和7.5% PVP-I（P < 0.1）。
在佩戴固定矫治器的正畸治疗患者中，OCT与CHX和PVP-I复合物相比具有优势（P≤ .1）。
