蛋白质预负荷对饮食控制的2型糖尿病患者碳水化合物餐后胃排空、血糖及肠道激素的影响。
Effects of a protein preload on gastric emptying, glycemia, and gut hormones after a carbohydrate meal in diet-controlled type 2 diabetes.
作者信息
Ma Jing, Stevens Julie E, Cukier Kimberly, Maddox Anne F, Wishart Judith M, Jones Karen L, Clifton Peter M, Horowitz Michael, Rayner Christopher K
机构信息
Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia.
出版信息
Diabetes Care. 2009 Sep;32(9):1600-2. doi: 10.2337/dc09-0723. Epub 2009 Jun 18.
OBJECTIVE
We evaluated whether a whey preload could slow gastric emptying, stimulate incretin hormones, and attenuate postprandial glycemia in type 2 diabetes.
RESEARCH DESIGN AND METHODS
Eight type 2 diabetic patients ingested 350 ml beef soup 30 min before a potato meal; 55 g whey was added to either the soup (whey preload) or potato (whey in meal) or no whey was given.
RESULTS
Gastric emptying was slowest after the whey preload (P < 0.0005). The incremental area under the blood glucose curve was less after the whey preload and whey in meal than after no whey (P < 0.005). Plasma glucose-dependent insulinotropic polypeptide, insulin, and cholecystokinin concentrations were higher on both whey days than after no whey, whereas glucagon-like peptide 1 was greatest after the whey preload (P < 0.05).
CONCLUSIONS
Whey protein consumed before a carbohydrate meal can stimulate insulin and incretin hormone secretion and slow gastric emptying, leading to marked reduction in postprandial glycemia in type 2 diabetes.
目的
我们评估了乳清蛋白预负荷是否能延缓2型糖尿病患者的胃排空、刺激肠促胰岛素激素分泌并减轻餐后血糖升高。
研究设计与方法
8名2型糖尿病患者在进食土豆餐30分钟前饮用350毫升牛肉汤；55克乳清蛋白分别添加到汤中（乳清蛋白预负荷组）或土豆中（餐中含乳清蛋白组），或不添加乳清蛋白。
结果
乳清蛋白预负荷组的胃排空最慢（P<0.0005）。乳清蛋白预负荷组和餐中含乳清蛋白组的血糖曲线下增量面积低于无乳清蛋白组（P<0.005）。在摄入乳清蛋白的两天里，血浆葡萄糖依赖性促胰岛素多肽、胰岛素和胆囊收缩素的浓度均高于无乳清蛋白组，而胰高血糖素样肽1在乳清蛋白预负荷组后最高（P<0.05）。
结论
碳水化合物餐前进食乳清蛋白可刺激胰岛素和肠促胰岛素激素分泌并延缓胃排空，从而显著降低2型糖尿病患者的餐后血糖。
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