Maier P, Reinhard T
Universitäts-Augenklinik Freiburg, Killianstrasse 5, 79106 Freiburg.
Ophthalmologe. 2009 Jul;106(7):649-62; quiz 663. doi: 10.1007/s00347-009-1943-z.
A number of corneal disorders sooner or later call for a decision as to whether corneal grafting is necessary. In contrast to the current gold standard, penetrating keratoplasty (PKP), former lamellar techniques had the disadvantage of worse visual outcomes due to interface problems. A number of recent new technical developments have led to a 'renaissance' of various lamellar keratoplasty methods. Deep anterior lamellar keratoplasty (DALK) avoids the risk of endothelial immune reactions. However, visual outcomes are comparable to PKP only is complete baring of Descemet's membrane is achieved. In Descemet stripping (automated) endothelial keratoplasty [DS(A)EK], a variation of posterior lamellar keratoplasty, only the diseased endothelium is removed with the Descetmet membrane (descemetorhexis). The lamellar, endothelium-bearing graft can subsequently be implanted via a corneoscleral/corneal tunnel, whereby little astigmatism is induced. The main advantage of DS(A)EK compared to PKP is faster visual recovery with almost unaltered refraction, although visual acuity is often slightly lower. However, valid study results are still lacking for this new surgical technique to allow a long-term comparison of the new techniques with conventional penetrating keratoplasty.
许多角膜疾病迟早需要决定是否有必要进行角膜移植。与当前的金标准穿透性角膜移植术(PKP)相比,以前的板层技术存在因界面问题导致视觉效果较差的缺点。最近的一些新技术发展导致了各种板层角膜移植方法的“复兴”。深前板层角膜移植术(DALK)避免了内皮免疫反应的风险。然而,只有在完全暴露Descemet膜的情况下,视觉效果才与PKP相当。在Descemet膜剥脱(自动)内皮角膜移植术[DS(A)EK]中,这是后板层角膜移植术的一种变体,仅去除带有Descemet膜(后弹力层剥除)的病变内皮。随后可以通过角巩膜/角膜隧道植入带有内皮的板层移植物,由此产生的散光很小。与PKP相比,DS(A)EK的主要优点是视力恢复更快,屈光几乎不变,尽管视力通常略低。然而,对于这种新的手术技术,仍然缺乏有效的研究结果来对新技术与传统穿透性角膜移植术进行长期比较。