碱性反流性食管炎
Alkaline reflux oesophagitis.
作者信息
Stoker D L, Williams J G
机构信息
St Bartholomew's Hospital, London.
出版信息
Gut. 1991 Oct;32(10):1090-2. doi: 10.1136/gut.32.10.1090.
Abstract
Duodenal and gastric contents do reflux into the oesophagus and acid alone certainly causes oesophageal damage which will be worsened by pepsin. In the patient who has undergone gastrectomy duodenal secretions may also be harmful. There is evidence that when the two mix there may be a toxic synergism, leading to mucosal disruption and intracellular damage to oesophageal cells which produces the clinical picture of reflux oesophagitis, with or without symptoms. Clear evidence of the toxicity of duodenal refluxate in humans is lacking, but the ability to measure bile and acid reflux continuously, together with a method of detecting oesophageal damage at a cellular level should help to solve this long debated problem.
摘要
十二指肠和胃内容物确实会反流至食管，仅胃酸就肯定会造成食管损伤，而胃蛋白酶会使这种损伤加剧。在接受过胃切除术的患者中，十二指肠分泌物也可能有害。有证据表明，当二者混合时，可能会产生毒性协同作用，导致黏膜破坏和食管细胞的细胞内损伤，从而出现反流性食管炎的临床表现，无论有无症状。目前缺乏十二指肠反流物对人体有毒性的确切证据，但能够连续测量胆汁和胃酸反流，以及在细胞水平检测食管损伤的方法，应该有助于解决这个长期存在争议的问题。
相似文献
1
Alkaline reflux oesophagitis.碱性反流性食管炎
Gut. 1991 Oct;32(10):1090-2. doi: 10.1136/gut.32.10.1090.
2
[Biliary reflux can be a contributory cause of esophagitis].胆汁反流可能是食管炎的一个促成因素。
Lakartidningen. 1998 Sep 16;95(38):4086-90.
3
[Is alkaline gastroesophageal reflux an etiology for esophagitis?].
Z Gastroenterol. 1997 Dec;35(12):1093-100.
4
Toxic bile acids in gastro-oesophageal reflux disease: influence of gastric acidity.胃食管反流病中的毒性胆汁酸：胃酸的影响
Gut. 1999 May;44(5):598-602. doi: 10.1136/gut.44.5.598.
5
The role of acid and bile reflux in oesophagitis and Barrett's metaplasia.酸和胆汁反流在食管炎和 Barrett 化生中的作用。
Biochem Soc Trans. 2010 Apr;38(2):348-52. doi: 10.1042/BST0380348.
6
Composition of gastro-oesophageal refluxate.胃食管反流物的成分
Gut. 1991 Oct;32(10):1093-9. doi: 10.1136/gut.32.10.1093.
7
'Bile' in the oesophagus.食管中的“胆汁”。
Br J Surg. 1993 Nov;80(11):1374-6. doi: 10.1002/bjs.1800801105.
8
Nocturnal gastric acidity pattern in gastro-oesophageal reflux disease with or without oesophagitis.伴有或不伴有食管炎的胃食管反流病的夜间胃酸模式。
Ital J Gastroenterol. 1995 Oct-Nov;27(8):413-8.
9
Active trypsin and reflux oesophagitis: an experimental study in rats.活性胰蛋白酶与反流性食管炎：大鼠实验研究
Br J Surg. 1982 May;69(5):269-72. doi: 10.1002/bjs.1800690513.
10
Bile and acid reflux in the pathogenesis of reflux oesophagitis in children.
J Paediatr Child Health. 2009 Jan-Feb;45(1-2):64-7. doi: 10.1111/j.1440-1754.2008.01431.x.
引用本文的文献
1
Integrated transcriptomic and metabolomic analyses reveal the mechanism by which quercetin inhibits reflux esophagitis in rats.整合转录组学和代谢组学分析揭示槲皮素抑制大鼠反流性食管炎的机制。
PLoS One. 2025 May 6;20(5):e0321959. doi: 10.1371/journal.pone.0321959. eCollection 2025.
2
Differences in the Characteristics of Barrett's Esophagus and Barrett's Adenocarcinoma between the United States and Japan.美国与日本之间巴雷特食管和巴雷特腺癌特征的差异。
ISRN Gastroenterol. 2013 Mar 28;2013:840690. doi: 10.1155/2013/840690. Print 2013.
3
Critical analysis of esophageal multichannel intraluminal impedance monitoring 20 years later.20年后对食管多通道腔内阻抗监测的批判性分析。
ISRN Gastroenterol. 2012;2012:903240. doi: 10.5402/2012/903240. Epub 2012 Oct 24.
4
Increased risk of laryngeal and pharyngeal cancer after gastrectomy for ulcer disease in a population-based cohort study.基于人群队列研究的胃切除术治疗溃疡病后喉和咽癌风险增加。
Br J Cancer. 2012 Mar 27;106(7):1342-5. doi: 10.1038/bjc.2012.72. Epub 2012 Mar 8.
5
Quality of life in GERD patients: medical treatment versus antireflux surgery.胃食管反流病患者的生活质量：药物治疗与抗反流手术对比
J Gastrointest Surg. 2006 Jul-Aug;10(7):934-9. doi: 10.1016/j.gassur.2006.04.001.
6
Pathogenesis of columnar-lined esophagus.柱状上皮化生食管的发病机制。
World J Gastroenterol. 2006 Mar 14;12(10):1521-8. doi: 10.3748/wjg.v12.i10.1521.
7
Association of laryngeal cancer with previous gastric resection.喉癌与既往胃切除术的关联。
Ann Surg. 2004 Nov;240(5):817-24. doi: 10.1097/01.sla.0000143244.76135.ca.
8
Role of intragastric and intraoesophageal alkalinisation in the genesis of complications in Barrett's columnar lined lower oesophagus.胃内和食管内碱化在Barrett柱状上皮化生的食管下段并发症发生中的作用
Gut. 1993 Jan;34(1):11-5. doi: 10.1136/gut.34.1.11.
9
Long-term ambulatory enterogastric reflux monitoring. Validation of a new fiberoptic technique.长期动态胃肠反流监测。一种新型光纤技术的验证。
Dig Dis Sci. 1993 Jul;38(7):1297-306. doi: 10.1007/BF01296082.
10
Mixed reflux of gastric and duodenal juices is more harmful to the esophagus than gastric juice alone. The need for surgical therapy re-emphasized.胃和十二指肠液的混合反流对食管的危害比单纯的胃液更大。再次强调了手术治疗的必要性。
Ann Surg. 1995 Oct;222(4):525-31; discussion 531-3. doi: 10.1097/00000658-199522240-00010.
本文引用的文献
1
Role of bile and pancreatic juice in production of esophageal erosions and anemia.胆汁和胰液在食管糜烂和贫血形成中的作用。
Proc Soc Exp Biol Med. 1951 Aug;77(4):862-6. doi: 10.3181/00379727-77-18950.
2
Gastropexy and "fundoplication" in surgical treatment of hiatal hernia.胃固定术和“胃底折叠术”在食管裂孔疝手术治疗中的应用
Am J Dig Dis. 1961 Oct;6:954-61. doi: 10.1007/BF02231426.
3
Esophagitis produced by reflux of duodenal contents in rats.大鼠十二指肠内容物反流所致食管炎
Am J Dig Dis. 1962 Jun;7:564-73. doi: 10.1007/BF02236137.
4
Subacute erosive ("peptic") esophagitis associated with achlorhydria.与胃酸缺乏相关的亚急性糜烂性（“消化性”）食管炎。
N Engl J Med. 1960 May 5;262:927-9. doi: 10.1056/NEJM196005052621807.
5
Oesophagitis following total gastrectomy: a follow-up study on 9 patients 5 years or more after operation.全胃切除术后食管炎：9例术后5年及以上患者的随访研究
Acta Chir Scand. 1960 Jan 30;118:190-201.
6
GASTRO-OESOPHAGEAL REFLUX AFTER PARTIAL GASTRECTOMY.胃部分切除术后的胃食管反流
Br Med J. 1964 Nov 14;2(5419):1233-4. doi: 10.1136/bmj.2.5419.1233.
7
Relative importance of biliary and pancreatic secretions in the genesis of esophagitis in rats.胆汁和胰腺分泌物在大鼠食管炎发生中的相对重要性
Am J Dig Dis. 1962 Nov;7:1026-33. doi: 10.1007/BF02231905.
8
Effects of the secretions of the stomach, duodenum, jejunum, and colon on the esophagus of the dog.
Surg Gynecol Obstet. 1958 Mar;106(3):337-42.
9
Reflux esophagitis.反流性食管炎
Am J Surg. 1957 Feb;93(2):228-33. doi: 10.1016/0002-9610(57)90771-7.
Zotero 插件