Vartiainen E, Korhonen H J, Pietinen P, Tuomilehto J, Kartovaara L, Nissinen A, Puska P
National Public Health Institute, Helsinki, Finland.
Int J Epidemiol. 1991 Sep;20(3):651-62. doi: 10.1093/ije/20.3.651.
The North Karelia Project, a major demonstration programme for coronary heart disease (CHD) prevention, was begun in an eastern province of Finland in 1972. A number of national CHD prevention activities have been undertaken, quite a few of them since 1977. This paper reports the 15-year changes in CHD risk factors (serum cholesterol, blood pressure, and smoking) in North Karelia and in the original reference area of the project, and more recent changes in a third area in southwestern Finland. The results are based on well-standardized, comparable surveys of cross-sectional populations, aged 30 to 59 years. The results indicate that risk factors reduced markedly in North Karelia from 1972-1977, to a lesser extent from 1977-1982, and only a little from 1982-1987. There was also a decline in the reference area during the first ten years (1972-1982) but the changes did not exceed those in North Karelia and during the second phase, from 1982-1987, risk factor changes were minor. Risk factor levels in the third area in southwestern Finland changed little from 1982-1987. Present serum cholesterol and blood pressure levels in North Karelia are still higher than in southwestern Finland, but smoking is less common among North Karelian men. These findings are discussed in the light of the recent information on Finnish dietary changes and CHD mortality; their bearing on the need for new cardiovascular disease prevention activities in Finland is also discussed.
北卡累利阿项目是一项预防冠心病的重大示范项目,于1972年在芬兰东部省份启动。自1977年以来开展了多项全国性的冠心病预防活动。本文报告了北卡累利阿以及该项目最初参照地区冠心病危险因素(血清胆固醇、血压和吸烟)的15年变化情况,以及芬兰西南部第三个地区的最新变化。研究结果基于对30至59岁横断面人群进行的标准化程度高且具有可比性的调查。结果表明,1972 - 1977年北卡累利阿的危险因素显著降低,1977 - 1982年降低幅度较小,1982 - 1987年仅略有下降。在最初十年(1972 - 1982年)参照地区也有下降,但变化幅度未超过北卡累利阿,在第二阶段,即1982 - 1987年,危险因素变化较小。芬兰西南部第三个地区的危险因素水平在1982 - 1987年变化不大。北卡累利阿目前的血清胆固醇和血压水平仍高于芬兰西南部,但北卡累利阿男性吸烟的情况较少。本文根据芬兰饮食变化和冠心病死亡率的最新信息对这些发现进行了讨论;还讨论了这些发现与芬兰开展新的心血管疾病预防活动必要性的关系。