1972 - 1987年芬兰东部肺炎衣原体感染的流行周期
The epidemic cycle of Chlamydia pneumoniae infection in eastern Finland, 1972-1987.
作者信息
Karvonen M, Tuomilehto J, Pitkäniemi J, Saikku P
机构信息
Department of Epidemiology, National Public Health Institute, Helsinki, Finland.
出版信息
Epidemiol Infect. 1993 Apr;110(2):349-60. doi: 10.1017/s0950268800068291.
The epidemic cycle of Chlamydia pneumoniae infection was examined in two areas in eastern Finland over a period of 15 years, 1972-87. The C. pneumoniae IgG antibody prevalence was determined with 5-year intervals in a random sample of the population aged 25-59 years. The total number of sera studied using immunofluorescence was 2387. In 1972 the antibody prevalence was 57% and it increased to 66% in 1977. Over the next 5 years the prevalence decreased to 44% in 1982, but by 1987 it had again increased to 59%. The temporal variation in prevalence was statistically significant (P < 0.001) and similar for both genders. Throughout the observation period the overall prevalence was 7-11% higher in men than in women (P < 0.01). The antibody prevalence increased with age, being the highest among the oldest study subjects of both genders. The periods of high and low prevalence alternated in an epidemic cycle (P < 0.001) of about 10 years.
1972年至1987年的15年间，在芬兰东部的两个地区对肺炎衣原体感染的流行周期进行了研究。每隔5年在25至59岁的随机抽样人群中测定肺炎衣原体IgG抗体流行率。使用免疫荧光法研究的血清总数为2387份。1972年抗体流行率为57%，1977年增至66%。在接下来的5年里，流行率在1982年降至44%，但到1987年又升至59%。流行率的时间变化具有统计学意义（P<0.001），且男女相似。在整个观察期内，男性的总体流行率比女性高7%至11%（P<0.01）。抗体流行率随年龄增长而增加，在两个性别的最年长研究对象中最高。高流行率和低流行率时期在大约10年的流行周期中交替出现（P<0.001）。
Zotero 插件