[关于葱属植物薤白中两种新呋甾烷醇糖苷的研究]

[Studies on two new furostanol glycosides from Allium macrostemon Bunge].

作者信息

Peng J P, Wang X, Yao X S

机构信息

Department of Phytochemistry, Shenyang College of Pharmacy.

出版信息

Yao Xue Xue Bao. 1993;28(7):526-31.

PMID:8285055

Abstract

Further studies on the active constituents in the bulbs of Allium macrostemon Bunge led to the isolation and structural determination of two new furostanol saponin macrostemonoside E and F. On the basis of chemical evidences and spectral analysis (UV, IR, 1H-NMR, 13C-NMR and FAB-MS), the structure of macrostemonoside E(I) was elucidated as (25R)-26-O-beta-D-glucopyranosyl-5 alpha-furost-20(22)-ene-3 beta,26-diol-3-O- beta-D-glucopyranosyl (1-->2) [beta-D-glucopyranosyl (1-->3)]-beta-D-glucopyranosyl (1-->4)-beta-D-galactopyranoside; macrostemonoside F(II) was established to be (25R)-26-O-beta-D-glucopyranosyl-5 beta-furost-20(22)-ene-3 beta,26-diol-3-O- beta-D-glucopyranosyl (1-->2)-beta-D-galactoside. Preliminary pharmacological tests showed that both macrostemonoside E and F could strongly inhibit ADP-induced human platelet aggregation in vitro. The IC50 of the former was 0.417 mM and that of the latter was 0.020 mM.

摘要

对薤白鳞茎中活性成分的进一步研究导致分离并确定了两种新的呋甾烷醇皂苷——薤白皂苷E和F的结构。基于化学证据和光谱分析（紫外、红外、¹H-核磁共振、¹³C-核磁共振和快原子轰击质谱），薤白皂苷E（I）的结构被阐明为（25R）-26-O-β-D-吡喃葡萄糖基-5α-呋甾-20（22）-烯-3β，26-二醇-3-O-β-D-吡喃葡萄糖基（1→2）[β-D-吡喃葡萄糖基（1→3）]-β-D-吡喃葡萄糖基（1→4）-β-D-吡喃半乳糖苷；薤白皂苷F（II）被确定为（25R）-26-O-β-D-吡喃葡萄糖基-5β-呋甾-20（22）-烯-3β，26-二醇-3-O-β-D-吡喃葡萄糖基（1→2）-β-D-半乳糖苷。初步药理试验表明，薤白皂苷E和F在体外均能强烈抑制ADP诱导的人血小板聚集。前者的IC50为0.417 mM，后者的IC50为0.020 mM。