Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Department of Pharmacy, Xi'an Medical University, Xi'an 710021, China.
Molecules. 2018 Mar 30;23(4):798. doi: 10.3390/molecules23040798.
Four new steroidal constituents (-) along with two known steroidal glycosides ( and ) were isolated from the roots and rhizomes of . Analysis of their physicochemical properties and spectroscopic profiles identified the compounds as (25)-5-spirostan-9(11)-en-3β, 17-diol (); (25)-5-spirostan-9(11)-en-3β, 12β-diol (); (25)-5-spirostan-9(11)-en-3β, 17-diol-3--β-d-glucopyranoside (); (25)-5-spirostan-9(11)-en-3β, 17-diol-3--β-d-glucopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-β-d-galactopyranoside (); japonicoside B (); and japonicoside C (). All six compounds showed cytotoxic activity against SMMC-7712, Bel-7402, A549, H460, and K562 human cancer cells.
从 的根和根茎中分离得到了四个新的甾体成分（-）和两个已知的甾体糖苷（和）。通过分析它们的理化性质和光谱特征，鉴定出这些化合物为（25）-5-螺甾烷-9（11）-烯-3β，17-二醇（）；（25）-5-螺甾烷-9（11）-烯-3β，12β-二醇（）；（25）-5-螺甾烷-9（11）-烯-3β，17-二醇-3--β-d-吡喃葡萄糖苷（）；（25）-5-螺甾烷-9（11）-烯-3β，17-二醇-3--β-d-吡喃葡萄糖基-（1→2）-[β-d-吡喃葡萄糖基-（1→3）]-β-d-半乳糖吡喃糖苷（）；日本薯蓣皂苷 B（）和日本薯蓣皂苷 C（）。所有六种化合物对 SMMC-7712、Bel-7402、A549、H460 和 K562 人癌细胞均显示细胞毒性活性。
