菝葜甾体成分的根及根茎。

Steroidal Constituents from Roots and Rhizomes of Smilacina japonica.

机构信息

Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.

Department of Pharmacy, Xi'an Medical University, Xi'an 710021, China.

出版信息

Molecules. 2018 Mar 30;23(4):798. doi: 10.3390/molecules23040798.

DOI:10.3390/molecules23040798

PMID:29601498

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6017528/

Abstract

Four new steroidal constituents (-) along with two known steroidal glycosides ( and ) were isolated from the roots and rhizomes of . Analysis of their physicochemical properties and spectroscopic profiles identified the compounds as (25)-5-spirostan-9(11)-en-3β, 17-diol (); (25)-5-spirostan-9(11)-en-3β, 12β-diol (); (25)-5-spirostan-9(11)-en-3β, 17-diol-3--β-d-glucopyranoside (); (25)-5-spirostan-9(11)-en-3β, 17-diol-3--β-d-glucopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-β-d-galactopyranoside (); japonicoside B (); and japonicoside C (). All six compounds showed cytotoxic activity against SMMC-7712, Bel-7402, A549, H460, and K562 human cancer cells.

摘要

从的根和根茎中分离得到了四个新的甾体成分（-）和两个已知的甾体糖苷（和）。通过分析它们的理化性质和光谱特征，鉴定出这些化合物为（25）-5-螺甾烷-9（11）-烯-3β，17-二醇（）；（25）-5-螺甾烷-9（11）-烯-3β，12β-二醇（）；（25）-5-螺甾烷-9（11）-烯-3β，17-二醇-3--β-d-吡喃葡萄糖苷（）；（25）-5-螺甾烷-9（11）-烯-3β，17-二醇-3--β-d-吡喃葡萄糖基-（1→2）-[β-d-吡喃葡萄糖基-（1→3）]-β-d-半乳糖吡喃糖苷（）；日本薯蓣皂苷 B（）和日本薯蓣皂苷 C（）。所有六种化合物对 SMMC-7712、Bel-7402、A549、H460 和 K562 人癌细胞均显示细胞毒性活性。