Kobayashi Jun'ichi, Kubota Takaaki
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Nat Prod Rep. 2009 Jul;26(7):936-62. doi: 10.1039/b813006j. Epub 2009 May 8.
About two hundred Daphniphyllum alkaloids have so far been isolated from thirteen species of the genus Daphniphyllum. This comprehensive review summarizes all the research into the isolation and structure elucidation of these alkaloids reported since investigations began in 1996. The structures of the Daphniphyllum alkaloids are classified based on six Daphniphyllum alkaloids (daphniphylline, secodaphniphylline, yuzurimine, daphnilactone A, daphnilactone B and yuzurine); these are also a number of newly found skeletons. The biosynthetic pathways, total syntheses, and bioactivities of the Daphniphyllum alkaloids are also described.
迄今为止，已从13种交让木属植物中分离出约200种交让木生物碱。这篇综述总结了自1996年研究开始以来，关于这些生物碱的分离及结构解析的所有研究。交让木生物碱的结构是根据6种交让木生物碱（交让木碱、去氢交让木碱、紫玉盘素、交让木内酯A、交让木内酯B和紫玉盘碱）进行分类的；这些也是一些新发现的骨架。文中还描述了交让木生物碱的生物合成途径、全合成以及生物活性。
