Kank蛋白：结构、功能与疾病
Kank proteins: structure, functions and diseases.
作者信息
Kakinuma N, Zhu Y, Wang Y, Roy B C, Kiyama R
机构信息
Signaling Molecules Research Group, Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, AIST Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
出版信息
Cell Mol Life Sci. 2009 Aug;66(16):2651-9. doi: 10.1007/s00018-009-0038-y. Epub 2009 May 12.
Abstract
The Kank family of proteins, Kank1-Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the C-terminal region, with an additional motif, the KN motif, at the N-terminus. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors. Their relationship to diseases such as cancer, and to neuronal and developmental disorders, will be an important subject of future study.
摘要
Kank蛋白家族（Kank1-Kank4）的特点是具有独特的结构，N端区域有卷曲螺旋基序，C端区域有锚蛋白重复序列，且在N端还有一个额外的基序——KN基序。Kank1是通过对肾细胞癌中一个肿瘤抑制基因进行定位克隆获得的，而其他成员则是通过同源性搜索发现的。该家族通过包含PI3K/Akt和/或未知调节因子/效应器的信号通路参与肌动蛋白聚合和细胞运动的调节。它们与癌症等疾病以及神经和发育障碍的关系将是未来研究的一个重要课题。
相似文献
1
Kank proteins: structure, functions and diseases.Kank蛋白：结构、功能与疾病
Cell Mol Life Sci. 2009 Aug;66(16):2651-9. doi: 10.1007/s00018-009-0038-y. Epub 2009 May 12.
2
Kank proteins: a new family of ankyrin-repeat domain-containing proteins.Kank蛋白：一个新的含锚蛋白重复结构域的蛋白家族。
Biochim Biophys Acta. 2008 Feb;1780(2):128-33. doi: 10.1016/j.bbagen.2007.09.017. Epub 2007 Oct 4.
3
Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins.ANKK1 和 ANKK2 蛋白的锚蛋白结构域识别驱动蛋白家族成员 21A（KIF21A）的结构基础。
J Biol Chem. 2018 Jan 12;293(2):557-566. doi: 10.1074/jbc.M117.817494. Epub 2017 Nov 28.
4
Structural analyses of key features in the KANK1·KIF21A complex yield mechanistic insights into the cross-talk between microtubules and the cell cortex.结构分析 KANK1·KIF21A 复合物的关键特征，为微管和细胞皮层之间的串扰提供了机制见解。
J Biol Chem. 2018 Jan 5;293(1):215-225. doi: 10.1074/jbc.M117.816017. Epub 2017 Nov 20.
5
Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling.Kank通过PI3K-Akt信号通路中的14-3-3调节RhoA依赖的肌动蛋白应激纤维形成和细胞迁移。
J Cell Biol. 2008 May 5;181(3):537-49. doi: 10.1083/jcb.200707022.
6
KANK family proteins in cancer.KANK 家族蛋白与癌症。
Int J Biochem Cell Biol. 2021 Feb;131:105903. doi: 10.1016/j.biocel.2020.105903. Epub 2020 Dec 10.
7
A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma.
J Biol Chem. 2002 Sep 27;277(39):36585-91. doi: 10.1074/jbc.M204244200. Epub 2002 Jul 19.
8
Structural insights into ankyrin repeat-mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion.结构洞察：衔接蛋白 KANK1 通过锚蛋白重复序列识别粘着斑内的驱动蛋白 KIF21A
J Biol Chem. 2018 Feb 9;293(6):1944-1956. doi: 10.1074/jbc.M117.815779. Epub 2017 Dec 7.
9
Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1.Kank通过阻止IRSp53与Rac1之间的相互作用来减弱肌动蛋白重塑。
J Cell Biol. 2009 Jan 26;184(2):253-67. doi: 10.1083/jcb.200805147.
10
Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model.KN 基序和 AnKyrin 重复结构域 1（KANK1）缺失导致小鼠模型中淋巴组织失调。
Genes (Basel). 2023 Oct 16;14(10):1947. doi: 10.3390/genes14101947.
引用本文的文献
1
Bibliometric analysis of MXRA7 gene research trajectory: trends and insights (2015-2024).MXRA7基因研究轨迹的文献计量分析：趋势与见解（2015 - 2024年）
Discov Oncol. 2025 Jun 3;16(1):989. doi: 10.1007/s12672-025-02824-5.
2
Matrix Remodeling Associated Genes (MXRAs): structural diversity, functional significance, and therapeutic potential in tumor microenvironments.基质重塑相关基因（MXRAs）：肿瘤微环境中的结构多样性、功能意义及治疗潜力
Discov Oncol. 2025 May 20;16(1):833. doi: 10.1007/s12672-025-02728-4.
3
Pan-Cancer Analysis of KANK2: Clinical and Molecular Insights into Tumor Progression and Therapeutic Implications.KANK2的泛癌分析：对肿瘤进展的临床和分子见解及治疗意义
J Cancer. 2025 Jan 6;16(4):1149-1166. doi: 10.7150/jca.105098. eCollection 2025.
4
The Protective Role of KANK1 in Podocyte Injury.KANK1 在足细胞损伤中的保护作用。
Int J Mol Sci. 2024 May 27;25(11):5808. doi: 10.3390/ijms25115808.
5
A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model.一种 TrkB 和 TrkC 部分激动剂可恢复晚期阿尔茨海默病小鼠模型突触功能缺陷，并促进活性依赖性突触和小胶质细胞转录组变化。
Alzheimers Dement. 2024 Jul;20(7):4434-4460. doi: 10.1002/alz.13857. Epub 2024 May 23.
6
Exclusive expression of KANK4 promotes myofibroblast mobility in keloid tissues.KANK4 的特异性表达促进了瘢痕疙瘩组织中成纤维细胞的迁移。
Sci Rep. 2024 Apr 16;14(1):8725. doi: 10.1038/s41598-024-59293-z.
7
A Collagen10a1 mutation disrupts cell polarity in a medaka model for metaphyseal chondrodysplasia type Schmid.在施密德型干骺端软骨发育不良的青鳉模型中，胶原蛋白10a1突变会破坏细胞极性。
iScience. 2024 Mar 4;27(4):109405. doi: 10.1016/j.isci.2024.109405. eCollection 2024 Apr 19.
8
Identification of single nucleotide polymorphisms (SNPs) associated with chronic graft-versus-host disease in patients undergoing allogeneic hematopoietic cell transplantation.鉴定与异基因造血细胞移植后慢性移植物抗宿主病相关的单核苷酸多态性（SNPs）。
Support Care Cancer. 2023 Sep 21;31(10):587. doi: 10.1007/s00520-023-08044-3.
9
Shifting Paradigm from Gene Expressions to Pathways Reveals Physiological Mechanisms in Blood Pressure Control in Causation.从基因表达到途径的转变揭示了因果关系中血压控制的生理机制。
Int J Mol Sci. 2023 Jan 9;24(2):1262. doi: 10.3390/ijms24021262.
10
Kank1 Is Essential for Myogenic Differentiation by Regulating Actin Remodeling and Cell Proliferation in C2C12 Progenitor Cells.Kank1 通过调节 C2C12 祖细胞中的肌动蛋白重塑和细胞增殖对成肌分化至关重要。
Cells. 2022 Jun 26;11(13):2030. doi: 10.3390/cells11132030.
本文引用的文献
1
Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1.Kank通过阻止IRSp53与Rac1之间的相互作用来减弱肌动蛋白重塑。
J Cell Biol. 2009 Jan 26;184(2):253-67. doi: 10.1083/jcb.200805147.
2
Alternative promoters influence alternative splicing at the genomic level.可变启动子在基因组水平上影响可变剪接。
PLoS One. 2008 Jun 18;3(6):e2377. doi: 10.1371/journal.pone.0002377.
3
Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling.Kank通过PI3K-Akt信号通路中的14-3-3调节RhoA依赖的肌动蛋白应激纤维形成和细胞迁移。
J Cell Biol. 2008 May 5;181(3):537-49. doi: 10.1083/jcb.200707022.
4
Folding landscapes of ankyrin repeat proteins: experiments meet theory.锚蛋白重复序列蛋白的折叠景观：实验与理论的交汇
Curr Opin Struct Biol. 2008 Feb;18(1):27-34. doi: 10.1016/j.sbi.2007.12.004.
5
IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions.IRSp53：在膜突起形成过程中跨越膜与肌动蛋白动力学之路。
Trends Cell Biol. 2008 Feb;18(2):52-60. doi: 10.1016/j.tcb.2007.12.002. Epub 2008 Jan 22.
6
Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities.两名患有智力障碍和发育障碍的患者中，细胞分裂素8的调控因子出现了功能紊乱。
Genomics. 2008 Feb;91(2):195-202. doi: 10.1016/j.ygeno.2007.10.011. Epub 2007 Dec 3.
7
The universal protein resource (UniProt).通用蛋白质资源（UniProt）。
Nucleic Acids Res. 2008 Jan;36(Database issue):D190-5. doi: 10.1093/nar/gkm895. Epub 2007 Nov 27.
8
Identification of genes involved in squamous cell carcinoma of the lung using synchronized data from DNA copy number and transcript expression profiling analysis.利用来自DNA拷贝数和转录本表达谱分析的同步数据鉴定与肺鳞状细胞癌相关的基因。
Lung Cancer. 2008 Mar;59(3):315-31. doi: 10.1016/j.lungcan.2007.08.037. Epub 2007 Oct 29.
9
Kank proteins: a new family of ankyrin-repeat domain-containing proteins.Kank蛋白：一个新的含锚蛋白重复结构域的蛋白家族。
Biochim Biophys Acta. 2008 Feb;1780(2):128-33. doi: 10.1016/j.bbagen.2007.09.017. Epub 2007 Oct 4.
10
Association of deletion 9p, 46,XY gonadal dysgenesis and autistic spectrum disorder.9p缺失、46，XY性腺发育不全与自闭症谱系障碍的关联。
Mol Hum Reprod. 2007 Sep;13(9):685-9. doi: 10.1093/molehr/gam045. Epub 2007 Jul 20.
Zotero 插件