Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Support Care Cancer. 2020 May;28(5):2361-2367. doi: 10.1007/s00520-019-05054-y. Epub 2019 Sep 5.
To investigate the relationship between physical function and quality of life in multiple myeloma patients.
In this retrospective cross-sectional study, data from patients with multiple myeloma (N = 63), who were referred to the department of Rehabilitation Medicine from October 2017 to May 2018, were reviewed. Patients were excluded based on the following criteria: acute illness, unstable medical conditions, impaired cognition or communication, refusal, or inability to perform the assessment. Physical function was evaluated with the Mini-Balance Evaluation Systems Test (Mini-BESTest), and the European Organization for Research and Treatment of Cancer questionnaires QLQ-C30 and QLQ-MY20 were used for the evaluation of quality of life. To evaluate fatigue and psychotic status, the Fatigue Severity Scale and Beck Depression Inventory were used. Patients were divided into two groups ("good-function group" and "poor-function group"), based on previously studied normative values of the Mini-BESTest. Clinical data was reviewed to interrogate the contributing factors of physical function.
Positive correlations were observed between Mini-BESTest scores and all domains of the QLQ-C30. The Mini-BESTest score was lower in patients with lower serum hemoglobin (r = 0.396, p = 0.001) and albumin levels (r = 0.440, p < 0.001), severe disease-related symptoms (r = - 0.39, p = 0.02), and depression (r = - 0.538, p < 0.001). Further, the poor-function group showed lower hemoglobin (p = 0.024) and albumin levels (p = 0.004).
In patients with multiple myeloma, physical function had a significant relationship with quality of life. Low hemoglobin and albumin levels, severe disease- or treatment-related symptoms, and depression were related to decreased physical function, and thus consequentially exert an effect on quality of life in multiple myeloma patients.
探讨多发性骨髓瘤患者的身体功能与生活质量之间的关系。
本回顾性横断面研究纳入了 2017 年 10 月至 2018 年 5 月期间因康复医学科就诊的 63 例多发性骨髓瘤患者。排除标准为：急性疾病、不稳定的医疗状况、认知或沟通障碍、拒绝或无法进行评估。使用 Mini-Balance Evaluation Systems Test（Mini-BESTest）评估身体功能，使用欧洲癌症研究与治疗组织问卷 EORTC QLQ-C30 和 QLQ-MY20 评估生活质量。使用 Fatigue Severity Scale 和 Beck Depression Inventory 评估疲劳和精神状态。根据 Mini-BESTest 的既往研究的参考值，将患者分为“功能良好组”和“功能不良组”。回顾临床数据以探讨身体功能的影响因素。
Mini-BESTest 评分与 EORTC QLQ-C30 的所有领域均呈正相关。血清血红蛋白（r = 0.396，p = 0.001）和白蛋白水平（r = 0.440，p < 0.001）较低、疾病相关症状严重（r = - 0.39，p = 0.02）和抑郁（r = - 0.538，p < 0.001）的患者 Mini-BESTest 评分较低。此外，功能不良组的血红蛋白（p = 0.024）和白蛋白水平（p = 0.004）较低。
多发性骨髓瘤患者的身体功能与生活质量显著相关。血红蛋白和白蛋白水平低、疾病或治疗相关症状严重以及抑郁与身体功能下降相关，进而对多发性骨髓瘤患者的生活质量产生影响。
