The University of Queensland, Children's Nutrition Research Centre, Herston, QLD, Australia.
Dysphagia. 2010 Mar;25(1):1-5. doi: 10.1007/s00455-009-9221-4. Epub 2009 Jun 26.
Research on the bioavailability of water from thickened fluids has recently been published and it concluded that the addition of certain thickening agents (namely, modified maize starch, guar gum, and xanthan gum) does not significantly alter the absorption of water from the healthy, mature human gut. Using xanthan gum as an example, our "proof of concept" study describes a simple, accurate, and noninvasive alternative to the methodology used in that first study, and involves the measurement and comparison of the dilution space ratios of the isotopes (2)H and (18)O and subsequent calculation of total body water. Our method involves the ingestion of a thickening agent labeled with (2)H 1 day after ingestion of (18)O. Analyses are based on the isotopic enrichment of urine samples collected prior to the administration of each isotope, and daily urine samples collected for 15 days postdosing. We urge that further research is needed to evaluate the impact of various thickening agents on the bioavailability of water from the developing gut and in cases of gut pathology and recommend our methodology.
最近发表了一项关于增稠液水分生物利用度的研究，其结论为，添加某些增稠剂（即改性玉米淀粉、瓜尔胶和黄原胶）并不会显著改变健康成熟人体肠道对水分的吸收。以黄原胶为例，我们的“概念验证”研究描述了一种简单、准确且非侵入性的替代方法，可用于替代第一项研究中使用的方法，涉及测量和比较同位素（2）H 和（18）O 的稀释空间比，以及随后计算总体水。我们的方法涉及在摄入（18）O 的 1 天后摄入标记有（2）H 的增稠剂。分析基于每个同位素给药前收集的尿液样本的同位素富集以及给药后 15 天每天收集的尿液样本。我们敦促需要进一步研究以评估各种增稠剂对发育中肠道水分生物利用度的影响以及在肠道病理的情况下，并推荐我们的方法。
