Hasan Sohel, Platta Harald W, Erdmann Ralf
Systembiochemie, Medizinische Fakultät, Ruhr-Universität Bochum Bochum, Germany.
Front Physiol. 2013 Sep 24;4:261. doi: 10.3389/fphys.2013.00261.
Peroxisomes constitute a dynamic compartment in all nucleated cells. They fulfill diverse metabolic tasks in response to environmental changes and cellular demands. This adaptation is implemented by modulation of the enzyme content of the organelles, which is accomplished by dynamically operating peroxisomal protein transport machineries. Soluble import receptors recognize their newly synthesized cargo proteins in the cytosol and ferry them to the peroxisomal membrane. Subsequently, the cargo is translocated into the matrix, where the receptor is ubiquitinated and exported back to the cytosol for further rounds of matrix protein import. This review discusses the recent progress in our understanding of the peroxisomal matrix protein import and its regulation by ubiquitination events as well as the current view on the translocation mechanism of folded proteins into peroxisomes. This article is part of a Special Issue entitled: Origin and spatiotemporal dynamics of the peroxisomal endomembrane system.
过氧化物酶体是所有有核细胞中的一个动态区室。它们根据环境变化和细胞需求完成各种代谢任务。这种适应性是通过调节细胞器的酶含量来实现的，这是由动态运行的过氧化物酶体蛋白转运机制完成的。可溶性导入受体在细胞质中识别其新合成的货物蛋白，并将它们运送到过氧化物酶体膜。随后，货物被转运到基质中，在那里受体被泛素化并运回细胞质，以便进行新一轮的基质蛋白导入。本综述讨论了我们对过氧化物酶体基质蛋白导入及其通过泛素化事件进行调控的最新理解进展，以及目前关于折叠蛋白转运到过氧化物酶体的机制的观点。本文是名为：过氧化物酶体内膜系统的起源和时空动态的特刊的一部分。
