18岁人群中P300波幅的遗传力不受青少年饮酒的影响。
The heritability of P300 amplitude in 18-year-olds is robust to adolescent alcohol use.
作者信息
Perlman Greg, Johnson Wendy, Iacono William G
机构信息
Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
出版信息
Psychophysiology. 2009 Sep;46(5):962-9. doi: 10.1111/j.1469-8986.2009.00850.x. Epub 2009 Jun 22.
Abstract
P3 amplitude reduction (P3AR) is associated with adolescent alcohol use (AAU) and highly heritable, suggesting that P3AR may index a genetic predisposition (e.g., an endophenotype) for AAU. However, because P3AR and AAU covary naturally in the population, these observations are also consistent with P3AR reflecting neurotoxic effects of AAU on the developing adolescent brain. In this report, we describe the use of recent advancements in biometric modeling to examine changes in the genetic and environmental contributions to variability in P3 amplitude related to cumulative AAU by late adolescence in a large community-based twin sample. We found that the genetic and environmental contributions to variability in P3 amplitude were unaffected by AAU. This suggests that P3AR indexes risk for alcoholism independent of any deleterious effect of AAU on adolescent brain development.
摘要
P3波幅降低（P3AR）与青少年饮酒（AAU）相关且具有高度遗传性，这表明P3AR可能是AAU遗传易感性（如一种内表型）的指标。然而，由于P3AR和AAU在人群中自然共变，这些观察结果也与P3AR反映AAU对发育中的青少年大脑的神经毒性作用一致。在本报告中，我们描述了利用生物统计学建模的最新进展，在一个基于社区的大型双胞胎样本中，研究与青春期晚期累积AAU相关的P3波幅变异性的遗传和环境贡献的变化。我们发现，AAU对P3波幅变异性的遗传和环境贡献没有影响。这表明P3AR是酒精中毒风险的指标，与AAU对青少年大脑发育的任何有害影响无关。
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