Perlman Greg, Markin Abraham, Iacono William G
Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Psychophysiology. 2013 Oct;50(10):974-82. doi: 10.1111/psyp.12081. Epub 2013 Aug 2.
P3 amplitude reduction (P3AR) is associated with risk for adolescent-onset pathological substance use (PSU). In this longitudinal study, data from over 1,100 adolescent twins were used to examine P3AR in relation to early adolescent onset PSU (i.e., by age 14), late adolescent onset PSU (i.e., ages 14-18), misuse of different classes of substances (PSU-nicotine, PSU-alcohol, PSU-illicit), degree of PSU comorbidity, and gender differences. P3 amplitude was recorded at age 14 from two midline electrodes during a visual oddball paradigm. PSU was defined as meeting criteria for any symptom of a substance use disorder assessed using semistructured clinical interviews. P3AR was associated with degree of drug class comorbidity, early adolescent onset PSU for all three substance classes, and late adolescent onset PSU for alcohol and illicit PSU. Gender differences in P3AR were not statistically significant. These findings provide further evidence that P3AR indexes a nonspecific diathesis for adolescent-onset PSU.
P3波幅降低（P3AR）与青少年期病理性物质使用（PSU）风险相关。在这项纵向研究中，来自1100多名青少年双胞胎的数据被用于检验P3AR与青少年早期开始的PSU（即14岁之前）、青少年晚期开始的PSU（即14 - 18岁）、不同类别物质的滥用（PSU - 尼古丁、PSU - 酒精、PSU - 非法药物）、PSU共病程度以及性别差异之间的关系。在视觉Oddball范式中，于14岁时从两个中线电极记录P3波幅。PSU被定义为符合使用半结构化临床访谈评估的物质使用障碍的任何症状标准。P3AR与药物类别共病程度、所有三类物质的青少年早期开始的PSU以及酒精和非法药物PSU的青少年晚期开始的PSU相关。P3AR的性别差异无统计学意义。这些发现提供了进一步的证据，表明P3AR是青少年期PSU的一种非特异性素质指标。
