Keane P A, Mand P S, Liakopoulos S, Walsh A C, Sadda S R
Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.
Br J Ophthalmol. 2009 Nov;93(11):1461-7. doi: 10.1136/bjo.2008.155846. Epub 2009 Jul 1.
To report the frequency and severity of retinal thickness measurement errors in a Fourier domain optical coherence tomography (FDOCT) device, Cirrus OCT.
Data from 209 eyes undergoing Cirrus OCT imaging with the Macular Cube protocol were collected. For each eye, the position of the automated retinal boundary lines used by the Cirrus OCT software for thickness calculations was assessed using a 6-point categorical scale. The presence of errors was correlated with various parameters including: retinal morphological features and disease diagnosis.
Errors of retinal boundary detection were observed in 57.5% of eyes but were severe in only 9.6% of eyes. The identification of subretinal fluid, subretinal tissue, pigment epithelium detachment or a diagnosis of choroidal neovascularisation was associated with more severe errors. Retinal cysts or a diagnosis of retinal vascular disease were less likely to be associated with significant error.
Retinal thickness measurement errors appear to occur less frequently with Fourier domain OCT (Cirrus OCT), but segmentation errors remain a concern, particularly in assessment of eyes with structurally complex retinal disease. With the recent release of multiple FDOCT systems, assessment of segmentation error may be an important factor in determining the relative merits of these systems.
报告傅里叶域光学相干断层扫描（FDOCT）设备Cirrus OCT中视网膜厚度测量误差的频率和严重程度。
收集209只接受Cirrus OCT黄斑立方协议成像的眼睛的数据。对于每只眼睛，使用6分分类量表评估Cirrus OCT软件用于厚度计算的自动视网膜边界线的位置。误差的存在与各种参数相关，包括：视网膜形态特征和疾病诊断。
57.5%的眼睛观察到视网膜边界检测误差，但只有9.6%的眼睛误差严重。视网膜下液、视网膜下组织、色素上皮脱离的识别或脉络膜新生血管的诊断与更严重的误差相关。视网膜囊肿或视网膜血管疾病的诊断与显著误差的相关性较小。
傅里叶域光学相干断层扫描（Cirrus OCT）中视网膜厚度测量误差似乎较少发生，但分割误差仍然是一个问题，特别是在评估具有结构复杂视网膜疾病的眼睛时。随着多个FDOCT系统的近期发布，分割误差的评估可能是确定这些系统相对优点的一个重要因素。
