Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.
Magn Reson Imaging. 2009 Dec;27(10):1319-25. doi: 10.1016/j.mri.2009.05.031. Epub 2009 Jul 3.
Magnetic Resonance Spectroscopic Imaging (MRSI) is a technique for imaging spatial variation of metabolites and has been very useful in characterizing biochemical changes associated with disease as well as response to therapy in malignant pathologies. This work presents a self-calibrated undersampling to accelerate 3D elliptical MRSI and an extrapolation-reconstruction algorithm based on the GRAPPA method. The accelerated MRSI technique was tested in three volunteers and five brain tumor patients. Acceleration allowed larger spatial coverage and consequently, less lipid contamination in spectra, compared to fully sampled acquisition within the same scantime. Metabolite concentrations measured from the accelerated acquisitions were in good agreement with measurements obtained from fully sampled MRSI scans.
磁共振波谱成像（MRSI）是一种用于成像代谢物空间变化的技术，在恶性病变中对疾病相关的生化变化以及对治疗的反应的特征具有非常重要的作用。本研究提出了一种基于 GRAPPA 方法的自校准欠采样加速 3D 椭圆 MRSI 和外推重建算法。在三名志愿者和五名脑肿瘤患者中对加速 MRSI 技术进行了测试。与在相同扫描时间内完全采样采集相比，加速采集允许更大的空间覆盖范围，从而减少了光谱中的脂质污染。从加速采集测量得到的代谢物浓度与从完全采样 MRSI 扫描中获得的测量值吻合良好。
