Mitchell E, Sethi S, Rowland M G, Chakraverty P, Harris E A, Watts M R, White P M
PHLS Communicable Disease Surveillance Centre, London.
J Public Health Med. 1991 Aug;13(3):214-8. doi: 10.1093/oxfordjournals.pubmed.a042621.
The Hong Kong H3N2 subtype of influenza A virus appeared in 1968 and since then has caused epidemics of varying degrees of severity. We describe a community outbreak of influenza A H3N2 which occurred in members of a bowls club in an English rural village in late April 1989. The explosive onset, high attack rate (34/41 = 83 per cent) in those exposed, and the clinical presentation initially suggested a toxic or allergic aetiology. Twenty-three persons consulted their general practitioners; before the diagnosis was made all cases were considered to merit antibiotic therapy and 17/23 were prescribed steroids or bronchodilators on account of persisting severe wheeze and chest tightness. One of the 23 was admitted to hospital. There were no deaths. Influenza vaccination is recommended for people at special risk but protective efficacy is relatively low and short-lived. Only two of the group had received influenza vaccination since the beginning of October 1988 and both became symptomatic. The use of amantadine for the prevention and early treatment of influenza A in selected situations merits serious consideration, provided the diagnosis is made sufficiently early.
甲型流感病毒香港H3N2亚型于1968年出现，自那时以来已引发了不同严重程度的疫情。我们描述了1989年4月下旬在英国一个乡村的保龄球俱乐部成员中发生的一次甲型H3N2流感社区暴发。其暴发迅速，暴露人群中的高发病率（34/41 = 83%），以及临床表现最初提示为中毒或过敏病因。23人咨询了他们的全科医生；在做出诊断之前，所有病例都被认为值得使用抗生素治疗，并且由于持续严重喘息和胸闷，23例中有17例被开了类固醇或支气管扩张剂。23例中有1例住院。无死亡病例。建议有特殊风险的人群接种流感疫苗，但保护效力相对较低且持续时间短。自1988年10月初以来，该群体中只有两人接种了流感疫苗，两人均出现了症状。在特定情况下，使用金刚烷胺预防和早期治疗甲型流感值得认真考虑，前提是诊断足够早。
