Carlini Andrea S, Adamiak Lisa, Gianneschi Nathan C
Department of Chemistry and Biochemistry, University of California, San Diego , La Jolla, California 92093, United States.
Macromolecules. 2016 Jun 28;49(12):4379-4394. doi: 10.1021/acs.macromol.6b00439. Epub 2016 Jun 21.
The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. As such, a diverse toolbox of polymerization techniques and bioconjugation methods has been developed. The greatest impact of this work has been in biomedicine and biotechnology, where fully synthetic and naturally derived biomolecules are used cooperatively. Despite significant improvements in biocompatible and functionally diverse polymers, our success in the field is constrained by recognized limitations in polymer architecture control, structural dynamics, and biostabilization. This Perspective discusses the current status of functional biosynthetic polymers and highlights innovative strategies reported within the past five years that have made great strides in overcoming the aforementioned barriers.
几十年来，生物分子编码功能聚合物的合成一直是一个广泛的研究领域。因此，已经开发出了各种各样的聚合技术和生物共轭方法工具箱。这项工作的最大影响在于生物医学和生物技术领域，其中全合成生物分子和天然衍生生物分子协同使用。尽管生物相容性和功能多样的聚合物有了显著改进，但我们在该领域的成功受到聚合物结构控制、结构动力学和生物稳定性方面公认的限制。本观点文章讨论了功能性生物合成聚合物的现状，并强调了过去五年中报道的在克服上述障碍方面取得重大进展的创新策略。
