Rehder Neto F C, Maeda F A, Turssi C P, Serra M C
Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
J Dent. 2009 Oct;37(10):786-90. doi: 10.1016/j.jdent.2009.06.008. Epub 2009 Jun 18.
To assess whether pastes containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and calcium sodium phosphosilicate (CSP) control artificial caries lesion progression.
Enamel slabs of bovine teeth were embedded in polyester resin and had their enamel surfaces serially polished, and tested for surface microhardness (SMH, 25 g, 5 s). Incipient caries-like lesions were pre-formed and specimens were evaluated by microhardness test (SMH(post-lesion)) and randomly assigned to five treatment groups (n=15): (1) regular dentifrice (RE, 1,100 ppm F); (2) dentifrice with calcium sodium phosphosilicate (CSP); (3) amorphous calcium phosphate stabilized by casein phosphopeptide (CPP-ACP); (4) CPP-ACP with 900 ppm F (CPP-ACP+F) and (5) control group-unexposed to any remineralizing agent. Treatments were applied five times, after the de-remineralization period in the cariogenic challenges. Post-treatments SMH measurements were conducted (SMH(post-treatment)).
ANOVA was applied for data evaluation and revealed a significant difference among the treatments (p=0.0161). Tukey's test was conducted and the percentage of mineral loss was calculated. Specimens exposed to CSP (7.1%), RE (6.7%) and CPP-ACP+F (3.8%) showed lower mineral loss than those that in the control group (-11.0%). CPP-ACP group (3.2%) differed from the control, CSP and RE groups.
Depending on the agent used, a remineralizing effect may be expected, which reflects in caries lesions progression.
评估含酪蛋白磷酸肽 - 无定形磷酸钙（CPP - ACP）和磷酸硅钙钠（CSP）的糊剂是否能控制人工龋损进展。
将牛牙釉质块嵌入聚酯树脂中，依次对其釉质表面进行抛光，并测试表面显微硬度（SMH，25 g，5 s）。预先形成早期龋样病变，通过显微硬度测试（病变后SMH）对标本进行评估，并随机分为五个治疗组（n = 15）：（1）普通牙膏（RE，1100 ppm氟）；（2）含磷酸硅钙钠（CSP）的牙膏；（3）由酪蛋白磷酸肽稳定的无定形磷酸钙（CPP - ACP）；（4）含900 ppm氟的CPP - ACP（CPP - ACP + F）和（5）对照组 - 未接触任何再矿化剂。在致龋挑战的脱矿化期后，将处理剂应用五次。进行处理后SMH测量（处理后SMH）。
应用方差分析进行数据评估，结果显示各处理组之间存在显著差异（p = 0.0161）。进行了Tukey检验并计算了矿物质损失百分比。暴露于CSP（7.1%）、RE（6.7%）和CPP - ACP + F（3.8%）的标本显示出比对照组（-11.0%）更低的矿物质损失。CPP - ACP组（3.2%）与对照组、CSP组和RE组不同。
根据所使用的试剂，可能会预期有再矿化效果，这反映在龋损进展中。
