Karimzadeh Sirvan, Farahpour Mohammad Reza
Indian J Exp Biol. 2017 Feb;55(2):98-106.
Salvia officinalis L. (common sage) is a popular herb in the mint family, Lamiaceae. To our knowledge, literature regarding the wound healing properties hydroethanolic extract of Salvia officinalis is scarce. Here, we tried to evaluate the in vitro antioxidant properties and in vivo wound healing activity of the hydroethanolic extract of S. officinalis. About 105 healthy Wistar rats were inflicted with wound by excision and incisionand were randomly divided into five experimental groups: Group I, as control; Group II, received placebo; groups III-V treated with 1, 3 and 5% S. officinalis hydroethanolic leaf extract, respectively. Thehydroethanolic leaf extract of Salvia officinalis showed the highest total flavonoid and phenolic content and antioxidant capacity. Topical application of S. officinalis extract, especially higher dose,significantly (P <0.05) increased the percentage of wound contraction, a period of re-epithelialization, breaking strength ratio and upregulated hydroxyproline content versus control group. Additionally, S. officinalis significantly (P <0.05) increased the new vessel formation and Fibroblast distribution. Our results showed that S. officinalis,especially S. officinalis 5%,were significantly promoting wound healing effect and can be considered as an appropriate compound for clinical application in wound care.
鼠尾草（药用鼠尾草）是唇形科薄荷属一种广受欢迎的草本植物。据我们所知，关于药用鼠尾草水乙醇提取物伤口愈合特性的文献很少。在此，我们试图评估药用鼠尾草水乙醇提取物的体外抗氧化特性和体内伤口愈合活性。约105只健康的Wistar大鼠通过切除和切开造成伤口，并随机分为五个实验组：第一组为对照组；第二组接受安慰剂；第三至五组分别用1%、3%和5%的药用鼠尾草水乙醇叶提取物处理。药用鼠尾草水乙醇叶提取物显示出最高的总黄酮和酚类含量以及抗氧化能力。局部应用药用鼠尾草提取物，尤其是高剂量，与对照组相比，显著（P<0.05）增加了伤口收缩百分比、再上皮化时间、断裂强度比并上调了羟脯氨酸含量。此外，药用鼠尾草显著（P<0.05）增加了新血管形成和成纤维细胞分布。我们的结果表明，药用鼠尾草，尤其是5%的药用鼠尾草，具有显著促进伤口愈合的作用，可被视为伤口护理临床应用的合适化合物。
