Salari Pooneh, Abdollahi Mohammad
Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Inflamm Allergy Drug Targets. 2009 Jul;8(3):169-75. doi: 10.2174/187152809788681065.
Bone turnover is much important in normal homeostasis of body skeleton. Medications, nutritional status, and systemic illnesses may affect bone metabolism by altering biochemical mediators. Prostaglandins, especially of E and F series are much important in bone physiology by affecting osteoclastic activity and osteoblastic differentiation. In bone fracture, production of prostaglandins affects fracture healing. There is the possibility that non-steroidal anti-inflammatory drugs (NSAIDs) affect bone health by inhibiting cyclooxygenase (COX) enzymes which reduce synthesis of prostaglandins. The aim of this paper is to review the effects of NSAIDs on bone by evaluating both animal and human studies. Using key words such as bone, bone marker, bone mineral density, NSAIDs, COX inhibitor, bone metabolism and search engines like Web of sciences, Scopus, Pubmed, and Google scholar, all relevant studies were collected. Although NSAIDs showed anti-resorptive properties in animal studies and some few human studies, to date no conclusive result has been observed in bone formation. Some limited studies reported higher bone mineral density in daily users of NSAIDs.
骨转换在人体骨骼的正常稳态中非常重要。药物、营养状况和全身性疾病可能通过改变生化介质来影响骨代谢。前列腺素，尤其是E系列和F系列，通过影响破骨细胞活性和成骨细胞分化，在骨生理学中非常重要。在骨折中，前列腺素的产生影响骨折愈合。非甾体抗炎药（NSAIDs）有可能通过抑制环氧化酶（COX）来影响骨骼健康，而环氧化酶会减少前列腺素的合成。本文的目的是通过评估动物和人体研究来综述NSAIDs对骨骼的影响。使用“骨”“骨标志物”“骨密度”“NSAIDs”“COX抑制剂”“骨代谢”等关键词以及Web of sciences、Scopus、Pubmed和谷歌学术等搜索引擎，收集了所有相关研究。尽管NSAIDs在动物研究和一些人体研究中显示出抗吸收特性，但迄今为止，在骨形成方面尚未观察到确凿的结果。一些有限的研究报告称，NSAIDs的日常使用者骨密度较高。
