小鼠Fv-1基因座的遗传学研究：在重组近交系中与Gpd-1的连锁关系
Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines.
作者信息
Taylor B A, Bedigian H G, Meier H
出版信息
J Virol. 1977 Jul;23(1):106-9. doi: 10.1128/JVI.23.1.106-109.1977.
Abstract
Multiple recombinant inbred lines, derived from crosses between strains permissive to N-tropic murine leukemia viruses (Fv-1n) and strains permissive to B-tropic murine leukemia viruses (Fv-1b), have been characterized as to Fv-1 genotype and other chromosome 4 markers, including the closely linked hexose-6-phosphate dehydrogenase isozyme locus (Gpd-1). Only one recombinant between Fv-1 and Gpd-1 was found among 45 lines tested. On this basis, the distance between Fv-1 and Gpd-1 is estimated to be 0.6 centimorgans. None of the lines was either resistant or susceptible to both N- and B-tropic viruses. Nineteen other inbred strains, previously untested, were characterized as either Fv-1n or Fv-1b.
摘要
多个重组近交系来源于对N-嗜性鼠白血病病毒（Fv-1n）敏感的品系与对B-嗜性鼠白血病病毒（Fv-1b）敏感的品系之间的杂交，这些重组近交系已根据Fv-1基因型和其他4号染色体标记进行了特征鉴定，包括紧密连锁的6-磷酸己糖脱氢酶同工酶基因座（Gpd-1）。在测试的45个品系中，仅发现一个Fv-1和Gpd-1之间的重组体。基于此，Fv-1和Gpd-1之间的距离估计为0.6厘摩。没有一个品系对N-和B-嗜性病毒均具有抗性或敏感性。另外19个以前未测试过的近交系被鉴定为Fv-1n或Fv-1b。
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