Stockert E, Boyse E A, Sato H, Itakura K
Proc Natl Acad Sci U S A. 1976 Jun;73(6):2077-81. doi: 10.1073/pnas.73.6.2077.
The GIX antigen is a feature of the gp70 envelope glycoprotein of murine luekemia virus (MuLV). This GIX-gp70 molecule is found on the thymocytes of some (GIX+) strains of mice, where its expression is controlled by two mendelian genes, Gv-1 and Gv-2. Previous recombination data involving the prototype GIX+ strain 129 indicated that the H-2 (chromosome 17) and Gv-1 loci are linked, at a distance of 36 units from one another. New data indicate that the association of H-2 and GIX phenotypes is an example of quasi-linkage, evidently dependent in this instance on heterozygosity at a locus or loci in the vicinity of H-2. Other previous recombination data, involving the GIX+ strain AKR, had indicated that the Gpd-1 (chromosome 4) and Gv-1 loci are linked at a distance of 19 units from one another. New data from other crosses show that this association of Gpd-1 (glucose-6-phosphate dehydrogenase 1) and GIX phenotypes also constitutes quasi-linkage, evidently due to heterozygosity at the Fv-1 locus. An important theoretical consequence of quasi-linkage in general is that it should enhance the heritability of particular constellations of unlinked genes, and so influence population structure. Our new data are discussed from the viewpoint that MuLV genomes are apparently concerned in quasi-linkage, and therefore by the same arguments may influence the genetic structure of populations. This in turn may strengthen the view that integrated MuLV genomes are not simply intruded into a self-sufficient cellular genome, but are themselves elements of the cellular genome with primary functions, perhaps in reproduction or embryogenesis.
GIX抗原是鼠白血病病毒(MuLV)gp70包膜糖蛋白的一个特征。这种GIX-gp70分子存在于某些(GIX+)品系小鼠的胸腺细胞上,其表达受两个孟德尔基因Gv-1和Gv-2控制。先前涉及原型GIX+品系129的重组数据表明,H-2(第17号染色体)和Gv-1位点是连锁的,彼此相距36个单位。新数据表明,H-2和GIX表型的关联是准连锁的一个例子,在这种情况下显然取决于H-2附近一个或多个位点的杂合性。先前涉及GIX+品系AKR的其他重组数据表明,Gpd-1(第4号染色体)和Gv-1位点彼此相距19个单位连锁。其他杂交的新数据表明,Gpd-1(葡萄糖-6-磷酸脱氢酶1)和GIX表型的这种关联也构成准连锁,显然是由于Fv-1位点的杂合性。一般来说,准连锁的一个重要理论结果是,它应该增强非连锁基因特定组合的遗传力,从而影响种群结构。我们从MuLV基因组显然与准连锁有关的观点来讨论我们的新数据,因此根据同样的论点,它可能会影响种群的遗传结构。这反过来可能会强化这样一种观点,即整合的MuLV基因组不仅仅是侵入一个自给自足的细胞基因组,而是细胞基因组本身具有主要功能的元件,可能在繁殖或胚胎发育中起作用。