Liew YinPing, Rafey Mohammed A, Allam Sridhar, Arrigain Susana, Butler Robert, Schreiber Martin
Department of Nephrology and Hypertension, Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
J Clin Hypertens (Greenwich). 2009 Apr;11(4):201-6. doi: 10.1111/j.1751-7176.2009.00096.x.
The association of optimal blood pressure (BP) control and arterial stiffness was evaluated in 172 patients with chronic kidney disease. The authors compared the augmentation index (AIx) of patients who achieved a recommended BP goal (<130/80 mm Hg) with those who did not (> or = 130/80 mm Hg). The median age was 57 years, 60% were male, and 70% were Caucasian. One-third of patients had achieved a BP goal of <130/80 mm Hg. AIx was significantly lower in patients who achieved BP goal than in those who did not (median AIx, 19% vs 23%; P=.04). AIx remained significantly lower in patients who achieved the BP goal, after adjusting for age, sex, and height (mean effect on AIx, -3.3%; 95% confidence interval, -6.1% to -0.4%; P=.03). Achievement of BP goal of <130/80 mm Hg in chronic kidney disease patients is associated with significantly lower AIx and may reflect a reduction in overall arterial stiffness.
在172例慢性肾病患者中评估了最佳血压（BP）控制与动脉僵硬度之间的关联。作者比较了达到推荐血压目标（<130/80 mmHg）的患者与未达到该目标（≥130/80 mmHg）的患者的增强指数（AIx）。患者的中位年龄为57岁，60%为男性，70%为白种人。三分之一的患者达到了<130/80 mmHg的血压目标。达到血压目标的患者的AIx显著低于未达到目标的患者（中位AIx，19%对23%；P=0.04）。在调整年龄、性别和身高后，达到血压目标的患者的AIx仍然显著较低（对AIx的平均影响为-3.3%；95%置信区间为-6.1%至-0.4%；P=0.03）。慢性肾病患者达到<130/80 mmHg的血压目标与显著较低的AIx相关，这可能反映了总体动脉僵硬度的降低。
