美味猕猴桃（奇异果），一种用于急性烧伤创面酶促清创的新药。

Actinidia deliciosa (kiwifruit), a new drug for enzymatic debridement of acute burn wounds.

作者信息

Hafezi Farhad, Rad Hamid Elmi, Naghibzadeh Bijan, Nouhi Amirhossein, Naghibzadeh Ghazal

机构信息

Iran University of Medical Sciences, St. Fatima Hospital, Tehran, Iran.

出版信息

Burns. 2010 May;36(3):352-5. doi: 10.1016/j.burns.2009.04.021. Epub 2009 Jul 17.

DOI:10.1016/j.burns.2009.04.021

PMID:19616384

Abstract

BACKGROUND

Actinidia deliciosa (kiwifruit) is used as a meat tenderizer. It acts rapidly and efficiently to soften meat, liquefying it if allowed to work for more than a few hours. Observing this effect and the lack of studies addressing this subject in the literature, the authors sought to investigate the use of this natural remedy in an animal model for eschar separation and debridement.

METHODS

Thirty-five male rats were divided randomly into three groups. Under general anaesthesia, a limited standard full-thickness burn was produced on the back of each rat. For the intervention group (G1, 15 rats), the wounds were covered with fresh kiwifruit; for control groups 2 and 3 (G2, 15 rats; G3, five rats), the dressing was a neutral ointment (Emulsifier 1220). Weekly wound observations were documented for all the groups. G1 and G2 were sacrificed on Day 20, and group 3 was kept alive until complete eschar separation. The wounds of the rats in groups 1 and 2 were excised and subjected to microscopic evaluation.

RESULTS

On Day 20, all eschars had detached and fallen off in the intervention group (G1), whereas in groups G2 and G3 the eschars were still firmly attached to the base of the wounds (except in two rats of G2); this finding was statistically significant (p<0.001). The average wound surface area in group G1 was 212 mm(2) (SD=88.80938) whereas in G2 it was 388 mm(2) (SD=140.6967). Thus, the wound surface area was significantly (p<0.001) smaller in the intervention group. The eschars in G3 separated spontaneously between days 30 and 42, while in all the rats of the kiwi-treated group, this phenomenon occurred before Day 20. The pathological study revealed no considerable differences between G1 and G2 (p<0.05).

CONCLUSIONS

Debridement and scar contraction occurred faster in the kiwi-treated group than in the untreated group. Following rapid enzymatic debridement, healing appeared to progress normally, with no evidence of damage to adjacent healthy tissue.

摘要

背景

美味猕猴桃（奇异果）被用作肉类嫩化剂。它能迅速且有效地软化肉类，若放置数小时以上，肉会被液化。观察到这种效果且文献中缺乏针对该主题的研究，作者试图在动物模型中研究这种天然疗法用于焦痂分离和清创的情况。

方法

35只雄性大鼠随机分为三组。在全身麻醉下，给每只大鼠背部造成标准的有限全层烧伤。干预组（G1，15只大鼠）的伤口用新鲜奇异果覆盖；对照组2和3（G2，15只大鼠；G3，5只大鼠），敷料为中性软膏（乳化剂1220）。对所有组每周进行伤口观察并记录。G1和G2在第20天处死，G3存活至焦痂完全分离。切除第1组和第2组大鼠的伤口并进行显微镜评估。

结果

在第20天，干预组（G1）所有焦痂已分离脱落，而在G2和G3组中，焦痂仍牢固附着于伤口底部（G2组的两只大鼠除外）；这一发现具有统计学意义（p<0.001）。G1组的平均伤口表面积为212平方毫米（标准差=88.80938），而G2组为388平方毫米（标准差=140.6967）。因此，干预组的伤口表面积显著更小（p<0.001）。G3组的焦痂在第30天至42天之间自发分离，而在所有用奇异果治疗的大鼠组中，这种现象在第20天之前就已发生。病理研究显示G1和G2之间无显著差异（p<0.05）。