芦荟提取物与磺胺嘧啶银对实验大鼠烧伤创面愈合效果的比较
Comparison of healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model.
作者信息
Akhoondinasab Mohammad Reza, Akhoondinasab Motahhare, Saberi Mohsen
机构信息
Faculty of Plastic and Reconstructive Surgery, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran;
Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;
出版信息
World J Plast Surg. 2014 Jan;3(1):29-34.
BACKGROUND
Wound healing is widely discussed in the medical literature. This study compared the healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model.
METHODS
Sixteen rats were randomly assigned to one of two groups, each group 8 rats. A deep second-degree burn on the lower back and 3(rd) degree burn on upper back of each rat were created with a standard burning procedure. Burns were dressed daily with aloe vera extract in group 2 and silver sulfadiazine in group 1. Response to treatment was assessed by digital photography during treatment until day 32. Histological parameters (PMN, epithelialization, fibrosis and angiogenesis) were assessed after biopsy of scar at the end of research.
RESULTS
Wound healing was more visible in aloe vera group. Also the speed of healing in aloe vera group was better than silver sulfadiazine group.
CONCLUSIONS
Based on our findings, aloe vera can be a therapy of choice for burn injuries.
背景
伤口愈合在医学文献中得到广泛讨论。本研究在实验大鼠模型中比较了芦荟提取物和磺胺嘧啶银对烧伤的愈合效果。
方法
将16只大鼠随机分为两组，每组8只。采用标准烧伤程序在每只大鼠的下背部造成深二度烧伤，在上背部造成三度烧伤。第2组大鼠的烧伤创面每天用芦荟提取物换药，第1组大鼠的烧伤创面每天用磺胺嘧啶银换药。在治疗至第32天期间，通过数码摄影评估治疗反应。在研究结束时对瘢痕进行活检后，评估组织学参数（中性粒细胞、上皮化、纤维化和血管生成）。
结果
芦荟组的伤口愈合更明显。此外，芦荟组的愈合速度优于磺胺嘧啶银组。
结论
基于我们的研究结果，芦荟可作为烧伤的首选治疗方法。
Zotero 插件