Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology (Formerly SRM University), Chennai, India.
Biomed Res Int. 2017;2017:5349520. doi: 10.1155/2017/5349520. Epub 2017 Dec 13.
The present study was designed to evaluate antiosteoporotic activity of the fresh juice mixtures obtained from and as well as the pericarp extract of on postmenopausal osteoporosis. 3-month-old female Wistar rats were ovariectiomized and the treatment began 14 days after ovariectomy and continued for 40 days. Statistically significant changes were noticed in body weight, ash weight, bone mineral content, and femur length and weight followed by serum evaluation and histopathology of femur bone. Administration of the fresh juice mixtures of the fruits of and prevented ovariectomy-induced bone loss. The administration of the fresh juice mixtures resulted in an increase in the femur length and weight, followed by an increase in the body weight as well as the calcium content obtained from the ash of the femur bone. It is evident that the fresh juice mixtures can be used as a remedy as well as a prophylactic for the prevention of postmenopausal osteoporosis. The present study showed that the combined effect of the fruit juice mixtures of and was found to be a better treatment for postmenopausal osteoporosis when compared to the pericarp extract of .
本研究旨在评估从 和 获得的新鲜果汁混合物以及 的果皮提取物对绝经后骨质疏松症的抗骨质疏松活性。3 月龄雌性 Wistar 大鼠去卵巢，去卵巢后 14 天开始治疗，持续 40 天。体重、骨灰重量、骨矿物质含量和股骨长度和重量均发生了统计学上的显著变化，随后进行了血清评估和股骨骨组织病理学检查。两种水果的新鲜果汁混合物的给药可预防去卵巢引起的骨丢失。给药后股骨长度和重量增加，随后体重以及股骨骨灰中的钙含量增加。显然，新鲜果汁混合物可用作绝经后骨质疏松症的治疗药物和预防药物。本研究表明，与 相比， 和 的混合果汁的联合作用被发现是治疗绝经后骨质疏松症的更好方法。
