A Comparative Study of and in Ovariectomy-Induced Osteoporosis in Female Wistar Rats.

The present study was designed to evaluate antiosteoporotic activity of the fresh juice mixtures obtained from and as well as the pericarp extract of on postmenopausal osteoporosis. 3-month-old female Wistar rats were ovariectiomized and the treatment began 14 days after ovariectomy and continued for 40 days. Statistically significant changes were noticed in body weight, ash weight, bone mineral content, and femur length and weight followed by serum evaluation and histopathology of femur bone. Administration of the fresh juice mixtures of the fruits of and prevented ovariectomy-induced bone loss. The administration of the fresh juice mixtures resulted in an increase in the femur length and weight, followed by an increase in the body weight as well as the calcium content obtained from the ash of the femur bone. It is evident that the fresh juice mixtures can be used as a remedy as well as a prophylactic for the prevention of postmenopausal osteoporosis. The present study showed that the combined effect of the fruit juice mixtures of and was found to be a better treatment for postmenopausal osteoporosis when compared to the pericarp extract of .