Osuch Elizabeth A, Bluhm Robyn L, Williamson Peter C, Théberge Jean, Densmore Maria, Neufeld Richard W J
Department of Psychiatry, University of Western Ontario, London, ON N6A3H8, Canada.
Neuroreport. 2009 Aug 26;20(13):1204-8. doi: 10.1097/WNR.0b013e32832f4da3.
Reward-processing neurocircuitry has been delineated using verbal or visual processing and/or decision-making tasks. We examined more basic processes of listening to enjoyable music in healthy and depressed patients. The paradigm was passive, individualized, and brief. Sixteen depressed and 15 control individuals provided favorite music and identified neutral music from selections provided. In the fMRI scanner, individuals heard their neutral and their favorite music for 3 min each. Favorite versus neutral music-listening contrasts showed greater activation in controls than depressed patients in medial orbital frontal cortex and nucleus accumbens/ventral striatum. Left medial prefrontal cortex activity was positively correlated with pleasure scores, whereas middle temporal cortex and globus pallidus were negatively correlated with pleasure. This paradigm activated neurocircuitry of reward processing and showed clinically meaningful alterations in depression.
奖赏处理神经回路已通过语言或视觉处理和/或决策任务进行了描绘。我们研究了健康和抑郁症患者聆听愉悦音乐的更基本过程。该范式是被动的、个性化的且简短的。16名抑郁症患者和15名对照个体提供了他们喜欢的音乐，并从提供的曲目中识别出中性音乐。在功能磁共振成像扫描仪中，个体分别聆听他们的中性音乐和喜欢的音乐各3分钟。与聆听中性音乐相比，聆听喜欢的音乐时，对照组在内侧眶额皮质和伏隔核/腹侧纹状体的激活程度高于抑郁症患者。左侧内侧前额叶皮质的活动与愉悦得分呈正相关，而颞中皮质和苍白球与愉悦感呈负相关。这种范式激活了奖赏处理神经回路，并显示出抑郁症患者存在具有临床意义的改变。
