Wu Yong-Ning, Zhao Yun-Feng, Li Jin-Guang
Department of Monitoring and Control for Contaminants and Residues, Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Biomed Environ Sci. 2009 Apr;22(2):95-9. doi: 10.1016/S0895-3988(09)60028-3.
To investigate the occurrence and concentrations of melamine and its analogues in tainted infant formula and to identify the etiologic factors for the urinary stones epidemic in infants and young children in China in 2008.
Sanlu infant formula samples were collected from families of the affected children in Gansu province, and markets in Gansu and Hebei provinces and Beijing city. Melamine and its analogues, including cyanuric acid, ammeline, and ammelide were measured by gas chromatography/tandem mass spectrometry.
High prevalence and concentrations of melamine were found in Sanlu infant formula samples, with low concentrations of cyanuric acid, ammeline and ammelide. Melamine were detected in 87 out of 111 Sanlu infant formula samples with a range of 118 to 4,700 mg/kg.
The results provide strong evidence for melamine as the etiological factor for the urinary stones epidemic in infants and young children in China in 2008.
调查受污染婴幼儿配方奶粉中三聚氰胺及其类似物的出现情况和浓度，并确定2008年中国婴幼儿尿路结石流行的病因。
从甘肃省受影响儿童家庭以及甘肃省、河北省和北京市的市场采集三鹿婴幼儿配方奶粉样本。采用气相色谱/串联质谱法测定三聚氰胺及其类似物，包括三聚氰酸、蜜胺和三聚氰二酰胺。
三鹿婴幼儿配方奶粉样本中三聚氰胺的检出率和浓度都很高，而三聚氰酸、蜜胺和三聚氰二酰胺的浓度较低。在111份三鹿婴幼儿配方奶粉样本中，有87份检测出三聚氰胺，含量范围为118至4700毫克/千克。
这些结果为三聚氰胺是2008年中国婴幼儿尿路结石流行的病因提供了有力证据。
