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在所谓的回旋加速器共振暴露条件下,未能重现人体淋巴细胞中钙摄取增加的情况。

Failure to reproduce increased calcium uptake in human lymphocytes at purported cyclotron resonance exposure conditions.

作者信息

Prasad A V, Miller M W, Carstensen E L, Cox C, Azadniv M, Brayman A A

机构信息

Department of Biophysics, School of Medicine and Dentistry, University of Rochester, NY 14642.

出版信息

Radiat Environ Biophys. 1991;30(4):305-20. doi: 10.1007/BF01210515.

DOI:10.1007/BF01210515
PMID:1961917
Abstract

An attempt was made to verify a report (Liboff et al. 1987) that a unique combination of DC and AC magnetic field exposures at room temperature results in a 3-fold increase in 45Ca2+ uptake by human lymphocytes in vitro. Exposures at "resonance condition", as well as at frequencies and amplitudes above and below the reported effective exposure conditions, were without effect, as were exposures at 37 degrees C. Treatment with ionomycin (0.25 microM), a positive control, resulted in a highly significant increase 45Ca2+ uptake. Some experiments were performed simultaneously by different investigators. Their results did not differ significantly. All experiments were conducted "double blindly".

摘要

有人试图验证一份报告(利博夫等人,1987年),该报告称在室温下将直流和交流磁场暴露进行独特组合,会使体外培养的人淋巴细胞对45Ca2+的摄取增加3倍。在“共振条件”下以及高于和低于报告的有效暴露条件的频率和振幅下进行暴露均无效果,在37摄氏度下暴露也是如此。用离子霉素(0.25微摩尔)作为阳性对照进行处理,导致45Ca2+摄取显著增加。一些实验由不同的研究人员同时进行。他们的结果没有显著差异。所有实验均采用“双盲”方式进行。

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本文引用的文献

1
Ionomycin stimulates T-lymphocytes to grow.离子霉素刺激T淋巴细胞生长。
Biochem Soc Trans. 1980 Dec;8(6):720-1. doi: 10.1042/bst0080720a.
2
Free cytoplasmic calcium concentration and the mitogenic stimulation of lymphocytes.游离细胞质钙浓度与淋巴细胞的有丝分裂原刺激
J Biol Chem. 1983 Apr 25;258(8):4876-82.
3
Total and exchangeable calcium in lymphocytes: effects of PHA and A23187.淋巴细胞中的总钙和可交换钙:PHA和A23187的作用
J Supramol Struct. 1980;14(1):65-75. doi: 10.1002/jss.400140107.
4
The early uptake of radioactive calcium by human lymphocytes treated with phytohaemagglutinin.用植物血凝素处理的人淋巴细胞对放射性钙的早期摄取。
Immunology. 1971 Sep;21(3):509-16.
5
Calcium cyclotron resonance and diatom mobility.钙回旋共振与硅藻迁移率
Bioelectromagnetics. 1987;8(3):215-27. doi: 10.1002/bem.2250080302.
6
Resonant ac-dc magnetic fields: calculated response.
Bioelectromagnetics. 1988;9(4):315-36. doi: 10.1002/bem.2250090402.
7
Search for cyclotron resonance in cells in vitro.体外细胞中回旋共振的研究。
Bioelectromagnetics. 1989;10(2):129-45. doi: 10.1002/bem.2250100203.
8
On the cyclotron resonance mechanism for magnetic field effects on transmembrane ion conductivity.关于磁场对跨膜离子电导率影响的回旋共振机制。
Bioelectromagnetics. 1988;9(4):381-5. doi: 10.1002/bem.2250090408.
9
Kinetics of channelized membrane ions in magnetic fields.磁场中通道化膜离子的动力学
Bioelectromagnetics. 1988;9(1):39-51. doi: 10.1002/bem.2250090104.
10
On the cyclotron resonance model of ion transport.关于离子输运的回旋共振模型。
Bioelectromagnetics. 1990;11(2):203-5. doi: 10.1002/bem.2250110210.