Department of Human Pathology and Oncology, University of Siena, Via delle Scotte, 6, 53100 Siena, Italy.
Semin Cancer Biol. 2009 Dec;19(6):401-6. doi: 10.1016/j.semcancer.2009.07.003. Epub 2009 Jul 18.
Since its discovery as the first human tumor virus, Epstein-Barr virus (EBV) has been implicated in the development of a wide range of B-cell lymphoproliferative disorders, the first being Burkitt lymphoma. However, the exact mechanism by which EBV promotes oncogenesis is still matter of discussion. A role in EBV-mediated transformation has been proposed for a novel described class of small non-coding RNAs, the microRNAs (miRNAs). EBV encodes viral miRNAs, through which it may interfere with the physiological regulation exterted by cellular miRNAs. In addition, EBV-coded proteins may also disturb the well-orchestrated mechanisms of regulation of cellular function. In this review, we will focus on the role of EBV in malignant transformation of Burkitt lymphoma, with a particular insight in the interplay between the virus and cellular miRNAs.
自被发现为第一种人类肿瘤病毒以来，Epstein-Barr 病毒（EBV）已被牵连到广泛的 B 细胞淋巴增生性疾病的发展中，第一个是伯基特淋巴瘤。然而，EBV 促进致癌的具体机制仍在讨论中。一类新描述的小非编码 RNA，即 microRNAs（miRNAs），被认为在 EBV 介导的转化中发挥作用。EBV 编码病毒 miRNA，通过它可能干扰细胞 miRNA 发挥的生理调节作用。此外，EBV 编码的蛋白质也可能干扰细胞功能调节的精心协调机制。在这篇综述中，我们将重点关注 EBV 在伯基特淋巴瘤恶性转化中的作用，特别关注病毒与细胞 miRNA 之间的相互作用。
