Patel Pragnesh D, Alghareeb Rahmah, Hussain Afshan, Maheshwari Marvi V, Khalid Nabeeha
Research, Saint George's University, School of Medicine, St. George's, GRD.
Research, College of Medicine, University of Baghdad, Baghdad, IRQ.
Cureus. 2022 Jun 25;14(6):e26314. doi: 10.7759/cureus.26314. eCollection 2022 Jun.
Epstein-Barr virus (EBV) is classified as a herpesvirus and is known for being one of the few viruses that can lead to the development of cancer. This study has gathered several studies to provide evidence as to this association as well as some of the mechanisms specific to EBV that allow this to happen. The development of EBV into cancer as well as the proteins involved in this oncogenesis play a crucial role in understanding this problem as well as creating a solution for mitigating this disease process in the future. This study summarized three of the most common malignancies caused by EBV in order to consolidate information about each of them. Additional emphasis was placed on finding which EBV serum markers were seen to be most indicative of prognosis and likelihood of developing malignancy. Higher serum EBV viral DNA loads were seen to be a useful indicator in assessing the risk of various cancers and should be studied further in relation to cancers that were not mentioned in this review.
爱泼斯坦-巴尔病毒（EBV）被归类为一种疱疹病毒，是已知的少数能够导致癌症发生的病毒之一。本研究收集了多项研究，以提供有关这种关联的证据，以及EBV特有的一些导致这种情况发生的机制。EBV发展为癌症以及参与这种肿瘤发生的蛋白质，在理解这个问题以及为未来减轻这种疾病进程创造解决方案方面起着至关重要的作用。本研究总结了由EBV引起的三种最常见的恶性肿瘤，以便整合关于每种肿瘤的信息。此外，重点放在找出哪些EBV血清标志物被认为最能指示预后和发生恶性肿瘤的可能性。较高的血清EBV病毒DNA载量被视为评估各种癌症风险的有用指标，对于本综述未提及的癌症，应进一步研究。
