Institute for Cancer Studies, School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Semin Cancer Biol. 2009 Dec;19(6):377-88. doi: 10.1016/j.semcancer.2009.07.004. Epub 2009 Jul 18.
Epstein-Barr virus was originally identified in the tumour cells of a Burkitt's lymphoma, and was the first virus to be associated with the pathogenesis of a human cancer. Studies on the relationship of EBV with Burkitt's lymphoma have revealed important general principles that are relevant to other virus-associated cancers. In addition, the impact of such studies on the knowledge of EBV biology has been enormous. Here, we review some of the key historical observations arising from studies on Burkitt's lymphoma that have informed our understanding of EBV, and we summarise the current hypotheses regarding the role of EBV in the pathogenesis of Burkitt's lymphoma.
EB 病毒最初在伯基特淋巴瘤的肿瘤细胞中被发现，是第一个与人类癌症发病机制相关的病毒。对 EBV 与伯基特淋巴瘤关系的研究揭示了一些重要的普遍原则，这些原则与其他病毒相关癌症有关。此外，这些研究对 EBV 生物学知识的影响是巨大的。在这里，我们回顾了一些源于伯基特淋巴瘤研究的关键历史观察结果，这些结果使我们对 EBV 有了更深入的了解，并总结了目前关于 EBV 在伯基特淋巴瘤发病机制中的作用的假设。
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