Ding Fuyun, Wang Yongqing, Liu Yun, Yao Weifeng, Yu Shuqin, Xu Guanglin
Nanjing Normal University, Nanjing 210046, China.
Zhongguo Zhong Yao Za Zhi. 2009 Apr;34(7):900-3.
To investigate the therapeutic effects of Ginkgo biloba extract (EGb) in rats with acute myocardial injury induced by isoproterenol (ISO).
The rats, induced by Isoproterenol (4 mg x kg(-1) x d(-1), 10 d, sc), were divided into groups: sham, model, metoprolol (10 mg x kg(-1) x d(-1), 13 d, ig), EGb (100 mg x kg(-1) x d(-1), 13 d, ig).
The cardiac parameters of the Model group were compromised significantly in both systolic and diastolic function. Improvement in cardiac function by EGb was significant. In model groups, plasma activities of AST, LDH, CK, HBDH, CKMB and ventricular weight index (LV and RV/BW) were elevated significantly. With the treatment with EGb and metoprolol, the enzymes and ventricular weight index were significantly ameliorated.
G. biloba extract was beneficial to cardiac performance by improving myocardium enzymes and cardiac function in isoproterenol induced myocardial injury in rats.
探讨银杏叶提取物（EGb）对异丙肾上腺素（ISO）诱导的大鼠急性心肌损伤的治疗作用。
用异丙肾上腺素（4mg·kg⁻¹·d⁻¹，皮下注射，共10天）诱导大鼠，将其分为假手术组、模型组、美托洛尔组（10mg·kg⁻¹·d⁻¹，灌胃，共13天）、EGb组（100mg·kg⁻¹·d⁻¹，灌胃，共13天）。
模型组的心脏参数在收缩和舒张功能方面均显著受损。EGb对心脏功能有显著改善作用。在模型组中，血浆中谷草转氨酶（AST）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、α-羟丁酸脱氢酶（HBDH）、肌酸激酶同工酶（CKMB）的活性以及心室重量指数（左心室和右心室/体重）均显著升高。经EGb和美托洛尔治疗后，这些酶和心室重量指数均得到显著改善。
在异丙肾上腺素诱导的大鼠心肌损伤中，银杏叶提取物通过改善心肌酶和心脏功能对心脏性能有益。
