Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Aliment Pharmacol Ther. 2009 Oct 15;30(8):873-80. doi: 10.1111/j.1365-2036.2009.04100.x. Epub 2009 Jul 18.
Oesophageal and gastric cancers comprise various common tumour types with possible different aetiology and historically different incidence trends.
To enhance and update evidence about the descriptive epidemiology of oesophageal and gastric cancers.
Population-based information from the East of England was available on 16 319 (65% male) incident cases of oesophago-gastric cancer (ICD-10 C150-169) diagnosed during 1995-2006. Age-standardized incidence trends by gender and deprivation groups and sex ratios were compared for four different tumour types [oesophageal squamous cell carcinoma (OSCC), oesophageal adenocarcinoma (OAC), junctional/cardia adenocarcinoma (JCA), and non-cardia gastric adenocarcinoma (NCGA)].
Between 1995-1997 and 2004-2006, the age-standardized incidence of OAC and JCA increased slightly (by 4% and 6% in men and 17% and 8% in women respectively), with a sex ratio >4 for both. Conversely, OSCC and NCGA incidence decreased (-20% and -32% in men and -15% and -26% in women respectively), with sex ratio of <2 for both. In men, OSCC and NCGA incidence was associated with increasing deprivation.
Within the study context, there was a modest rise in OAC and JCA incidence. OAC and JCA share common incidence trends and sociodemographic features (contrasting with those of OSCC and NCGA cancers).
食管癌和胃癌包含各种常见的肿瘤类型，其病因可能不同，历史发病率趋势也不同。
增强和更新有关食管癌和胃癌描述性流行病学的证据。
1995-2006 年期间，英国东部地区有 16319 例（65%为男性）食管癌和胃癌（ICD-10 C150-169）的发病病例，这些病例基于人群，可获得相关信息。按性别和贫困群体以及性别比比较了四种不同肿瘤类型（食管鳞状细胞癌（OSCC）、食管腺癌（OAC）、交界/贲门腺癌（JCA）和非贲门胃腺癌（NCGA））的年龄标准化发病率趋势。
1995-1997 年至 2004-2006 年期间，男性 OAC 和 JCA 的年龄标准化发病率略有上升（分别上升 4%和 6%，女性分别上升 17%和 8%），性别比均大于 4。相反，OSCC 和 NCGA 的发病率下降（男性分别下降 20%和 32%，女性分别下降 15%和 26%），性别比均小于 2。在男性中，OSCC 和 NCGA 的发病率与贫困程度的增加有关。
在研究背景下，OAC 和 JCA 的发病率略有上升。OAC 和 JCA 的发病率趋势和社会人口学特征（与 OSCC 和 NCGA 癌症相反）相似。
