Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA.
Angiology. 2010 Feb-Mar;61(1):100-6. doi: 10.1177/0003319709335028. Epub 2009 Jul 21.
This pilot study assessed the effects of hyperemia on carotid-radial pulse wave velocity (PWV) in 39 normotensive (NT) and 23 hypertensive (HT) participants using applanation tonometry. Pulse wave velocity was measured at 1- and at 2-minute intervals. Baseline PWV was similar between the groups (P = .59). At 1 minute, PWV decreased (8.5 +/- 1.2 to 7.1 +/- 1.4 m/s, P < .001) in NT but not in HT (P = .83). Hyperemic PWV (DeltaPWV) response differed between the groups (-16% vs + 1.0%, P < .001). On multivariate analysis, HT, not age or blood pressure was independently related to DeltaPWV (R(2) = .43, P < .01). Among patients with cardiovascular risk factors/disease, DeltaPWV was inversely related to flow-mediated dilation (FMD; R( 2) = .43, P < .003).
hyperemia decreases PWV(1min) in NT but not in HT. DeltaPWV is inversely related to FMD. Blunted hyperemic PWV response may represent impaired vasodilatory reserve.
本研究初步评估了应用平板容积描记法测量的 39 名正常血压（NT）和 23 名高血压（HT）患者充血后颈-桡动脉脉搏波速度（PWV）的变化。分别在 1 分钟和 2 分钟时测量脉搏波速度。两组患者的基线 PWV 无显著差异（P=0.59）。1 分钟时，NT 患者的 PWV 降低（从 8.5±1.2m/s 降至 7.1±1.4m/s，P＜0.001），而 HT 患者的 PWV 无显著变化（P=0.83）。两组患者的充血后 PWV 变化率（ΔPWV）不同（-16%比+1.0%，P＜0.001）。多变量分析显示，HT 而非年龄或血压与ΔPWV 独立相关（R2=0.43，P＜0.01）。在合并心血管危险因素/疾病的患者中，ΔPWV 与血流介导的舒张功能（FMD）呈负相关（R2=0.43，P＜0.003）。
NT 患者的 PWV（1min）在充血后降低，而 HT 患者无此变化。ΔPWV 与 FMD 呈负相关。充血后 PWV 反应迟钝可能提示血管舒张储备受损。
