Watanabe Ikue, Kuriyama Shinichi, Kakizaki Masako, Sone Toshimasa, Ohmori-Matsuda Kaori, Nakaya Naoki, Hozawa Atsushi, Tsuji Ichiro
Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Am J Clin Nutr. 2009 Sep;90(3):672-9. doi: 10.3945/ajcn.2009.27599. Epub 2009 Jul 22.
Experimental and animal studies have shown the activities of catechins, the main constituents of green tea, against infectious agents. No data are available on the association between green tea consumption and the risk of pneumonia in humans.
We examined the association between green tea consumption and death from pneumonia in humans.
We conducted a population-based cohort study, with follow-up from 1995 to 2006. The participants were National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y). We excluded participants for whom data on green tea consumption frequency were missing or who had reported a history of cancer, myocardial infarction, stroke, and extreme daily energy intake at baseline. We used Cox proportional hazards regression analysis to calculate hazard ratios (HRs) and their 95% CIs for death from pneumonia according to green tea consumption.
Over 12 y of follow-up, we documented 406 deaths from pneumonia. In women, the multivariate HRs of death from pneumonia that were associated with different frequencies of green tea consumption were 1.00 (reference) for <1 cup/d, 0.59 (95% CI: 0.36, 0.98) for 1-2 cups/d, 0.55 (95% CI: 0.33, 0.91) for 3-4 cups/d, and 0.53 (95% CI: 0.33, 0.83) for > or =5 cups/d, respectively (P for trend: 0.008). In men, no significant association was observed.
Green tea consumption was associated with a lower risk of death from pneumonia in Japanese women.
实验和动物研究表明，绿茶的主要成分儿茶素具有抗感染活性。目前尚无关于人类饮用绿茶与肺炎风险之间关联的数据。
我们研究了人类饮用绿茶与肺炎死亡之间的关联。
我们进行了一项基于人群的队列研究，随访时间为1995年至2006年。参与者为日本国民健康保险受益人（19079名男性和21493名年龄在40 - 79岁的女性）。我们排除了那些绿茶饮用频率数据缺失或在基线时报告有癌症、心肌梗死、中风病史以及每日能量摄入极端情况的参与者。我们使用Cox比例风险回归分析来计算根据绿茶饮用量得出的肺炎死亡风险比（HRs）及其95%置信区间（CIs）。
在12年的随访中，我们记录了406例肺炎死亡病例。在女性中，与不同绿茶饮用频率相关的肺炎死亡多变量HRs分别为：每天饮用少于1杯为1.00（参照），每天饮用1 - 2杯为0.59（95% CI：0.36，0.98），每天饮用3 - 4杯为0.55（95% CI：0.33，0.91），每天饮用≥5杯为0.53（95% CI：0.33，0.83）（趋势P值：0.008）。在男性中，未观察到显著关联。
饮用绿茶与日本女性较低的肺炎死亡风险相关。
