抗肿瘤聚醚大环内酯类化合物：从新西兰深水海洋海绵 Lissodendoryx sp. 中分离出的四种新海兔毒素
Antitumour polyether macrolides: four new halichondrins from the New Zealand deep-water marine sponge Lissodendoryx sp.
作者信息
Hickford Sarah J H, Blunt John W, Munro Murray H G
机构信息
Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
出版信息
Bioorg Med Chem. 2009 Mar 15;17(6):2199-203. doi: 10.1016/j.bmc.2008.10.093. Epub 2008 Nov 19.
The isolation is reported of four new variants of the halichondrin B skeleton, very minor potently bioactive components from the Poecilosclerid sponge Lissodendoryx sp. These compounds were isolated in microgram quantities only from a collection of 1tonne of sponge. The structural elucidations relied heavily on the use of capillary NMR spectroscopy and the application of an HSQC-DEPT overlay technique.
据报道，从苔藓海绵Lissodendoryx sp.中分离出了四种新的软海绵素B骨架变体，它们是非常微量但具有强效生物活性的成分。这些化合物仅从1吨海绵样品中以微克量分离得到。结构解析在很大程度上依赖于毛细管核磁共振光谱的使用以及HSQC-DEPT叠加技术的应用。
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