Kocaturk Ozgur, Kim Ann H, Saikus Christina E, Guttman Michael A, Faranesh Anthony Z, Ozturk Cengizhan, Lederman Robert J
Translational Medicine Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1061, USA.
J Magn Reson Imaging. 2009 Aug;30(2):461-5. doi: 10.1002/jmri.21844.
To develop an "active" (receiver-coil) clinical-grade guidewire with enhanced visibility for magnetic resonance imaging (MRI) and favorable mechanical characteristics for interventional MRI procedures that require conspicuous intravascular instruments distinguishable from surrounding tissues.
We designed a 0.035-inch guidewire combining two antenna designs on separate channels. A loop antenna visualizes the tip and a dipole antenna visualizes the whole shaft. We compared mechanical characteristics of this guidewire with x-ray alternatives and tested MRI performance at 1.5T in vitro and in vivo in swine.
Images reflected tip position within 0.97 +/- 0.42 mm and afforded whole-shaft visibility under expected conditions without sacrificing device size or handling. We report tip stiffness, torquability, and pushability comparable to commercial interventional guidewires.
Our clinical-grade 0.035-inch active guidewire is conspicuous under MRI and has mechanical performance comparable to x-ray interventional guidewires. This may enable a range of interventional procedures using real-time MRI.
开发一种“有源”（接收线圈）临床级导丝，其在磁共振成像（MRI）中具有增强的可视性，并且对于需要与周围组织区分开的明显血管内器械的介入MRI程序具有良好的机械特性。
我们设计了一种0.035英寸的导丝，在不同通道上结合了两种天线设计。一个环形天线显示导丝尖端，一个偶极天线显示整个导丝轴。我们将这种导丝的机械特性与X射线替代导丝进行了比较，并在1.5T场强下对猪进行了体外和体内MRI性能测试。
图像显示尖端位置的误差在0.97±0.42毫米以内，并且在不牺牲器械尺寸或操作性的预期条件下实现了整个导丝轴的可视性。我们报告该导丝的尖端硬度、扭转性和推送性与商用介入导丝相当。
我们的临床级0.035英寸有源导丝在MRI下很显眼，并且具有与X射线介入导丝相当的机械性能。这可能使一系列使用实时MRI的介入程序成为可能。
