精神分裂症患者外周组织中脑型肌酸磷酸激酶同工酶（CK BB）
[Creatine phosphokinase isoenzymes (CK BB) of the brain in peripheral tissues in schizophrenia].
作者信息
Aksenova M V, Karaseva N S, Burbaeva G Sh
出版信息
Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(10):36-8.
The activity and content of the brain isoenzyme of creatine phosphokinase-BB (CPK-BB) were investigated in the peripheral tissues containing this isoenzyme (in the small intestine and heart) in health and schizophrenia. The decrease of CPK-BB activity and content in schizophrenic brain was shown before. The present work demonstrates the reduction of CPK-BB activity and concentration not only in the brain of mental patients but also in the intestine and heart tissues. A high correlation was discovered between the CPK-BB level in the brain and in the intestine of schizophrenic patients (r = 0.85).
在健康人群和精神分裂症患者中，对含有肌酸磷酸激酶-BB（CPK-BB）同工酶的外周组织（小肠和心脏）中该脑同工酶的活性和含量进行了研究。此前已表明精神分裂症患者大脑中CPK-BB活性和含量降低。目前的研究表明，不仅精神病患者大脑中的CPK-BB活性和浓度降低，小肠和心脏组织中的也降低。发现精神分裂症患者大脑和小肠中的CPK-BB水平之间存在高度相关性（r = 0.85）。
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