Barczak Amy K, Hung Deborah T
Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, USA.
Curr Opin Microbiol. 2009 Oct;12(5):490-6. doi: 10.1016/j.mib.2009.06.012. Epub 2009 Jul 22.
Targeting virulence factors has gained increasing attention as a potential approach to new antibiotics. Small molecule inhibitors of virulence have been shown to change the course of disease in whole organism infection models. Recently, key advances in the field include the identification of novel targets within cell signaling pathways, a new class of anti-virulence compounds that target bacterial defenses against host immunity, and a growing body of in vivo data to support the general approach of anti-virulence therapies. Additionally, there has been a distinct trend toward developing broader spectrum anti-virulence compounds, in particular agents with activity against diverse Gram-negative organisms. Herein we provide an update on the status of the field with a focus on recent advancements.
靶向毒力因子作为开发新型抗生素的一种潜在方法，已越来越受到关注。毒力小分子抑制剂已被证明可在整体生物感染模型中改变疾病进程。最近，该领域的关键进展包括在细胞信号通路中鉴定出新的靶点、一类针对细菌抵御宿主免疫的新型抗毒力化合物，以及越来越多的体内数据支持抗毒力疗法的总体方法。此外，开发更广泛谱的抗毒力化合物，特别是对多种革兰氏阴性菌有活性的药物，已成为一种明显的趋势。在此，我们重点介绍该领域的最新进展，以提供该领域现状的最新情况。
