Laboratory of Microbiology Signals and Microenvironment, LMSM EA 4312, Normandy University, University of Rouen Normandy, Evreux, France,
Laboratory of Microbiology Signals and Microenvironment, LMSM EA 4312, Normandy University, University of Rouen Normandy, Evreux, France.
J Innate Immun. 2019;11(3):227-241. doi: 10.1159/000493926. Epub 2018 Nov 5.
Bacterial biofilms constitute a critical problem in hospitals, especially in resuscitation units or for immunocompromised patients, since bacteria embedded in their own matrix are not only protected against antibiotics but also develop resistant variant strains. In the last decade, an original approach to prevent biofilm formation has consisted of studying the antibacterial potential of host communication molecules. Thus, some of these compounds have been identified for their ability to modify the biofilm formation of both Gram-negative and Gram-positive bacteria. In addition to their effect on biofilm production, a detailed study of the mechanism of action of these human hormones on bacterial physiology has allowed the identification of new bacterial pathways involved in biofilm formation. In this review, we focus on the impact of neuropeptidic hormones on bacteria, address some future therapeutic issues, and provide a new view of inter-kingdom communication.
细菌生物膜是医院面临的一个重大问题，尤其是在复苏病房或免疫功能低下的患者中，因为嵌入其自身基质中的细菌不仅能抵抗抗生素，还会产生耐药变异株。在过去十年中，一种防止生物膜形成的新方法是研究宿主通讯分子的抗菌潜力。因此，已经确定了一些具有改变革兰氏阴性和革兰氏阳性细菌生物膜形成能力的化合物。除了对生物膜形成的影响外，这些人类激素对细菌生理学作用机制的详细研究还确定了参与生物膜形成的新细菌途径。在这篇综述中，我们重点关注神经肽激素对细菌的影响，探讨一些未来的治疗问题，并提供了一种新的种间通讯观点。
