Benice Ted S, Raber Jacob
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA.
Learn Mem. 2009 Jul 24;16(8):479-85. doi: 10.1101/lm.1428209. Print 2009 Aug.
Compared with age-matched male mice, female mice experience a more severe age-related cognitive decline (ACD). Since androgens are less abundant in aged female mice compared with aged male mice, androgen supplementation may enhance cognition in aged female mice. To test this, we assessed behavioral performance on a variety of tasks in 22- to 24-mo-old gonadally intact female mice treated for 6 wk with silastic capsules containing either testosterone (T) or dihydrotestosterone (DHT) or empty capsules (placebo). Compared with placebo-treated mice, spatial memory retention in the water maze was enhanced by testosterone treatment, but not DHT treatment. In contrast, DHT treatment improved passive avoidance (PA) retention, while T treatment only did so marginally. These data support that androgen supplementation in old female mice improves cognitive performance differentially depending upon the type of hormone treatment and cognitive task.
与年龄匹配的雄性小鼠相比，雌性小鼠经历更严重的与年龄相关的认知衰退（ACD）。由于老年雌性小鼠体内的雄激素比老年雄性小鼠少，补充雄激素可能会增强老年雌性小鼠的认知能力。为了验证这一点，我们评估了22至24月龄性腺完整的雌性小鼠在接受含有睾酮（T）或双氢睾酮（DHT）的硅橡胶胶囊或空胶囊（安慰剂）治疗6周后在各种任务中的行为表现。与接受安慰剂治疗的小鼠相比，睾酮治疗增强了水迷宫中的空间记忆保持能力，但双氢睾酮治疗没有。相反，双氢睾酮治疗改善了被动回避（PA）保持能力，而睾酮治疗仅略有改善。这些数据支持，老年雌性小鼠补充雄激素可根据激素治疗类型和认知任务的不同而改善认知表现。
